Bracketology by Jonathon Warriner
Updated January 16th, 2022
| South Region (San Antonio) | West Region (San Francisco) |
| 1.Auburn (Greenville) | 1.Gonzaga (Portland) |
| 16.Gardner-Webb/ Norfolk State | 16.Weber State |
| 8.Texas | 8.Colorado State |
| 9.North Carolina | 9.Oklahoma |
| 4.Iowa State (Portland) | 4.Xavier (Buffalo) |
| 13.Grand Canyon | 13.Ohio |
| 5.UCLA | 5.Illinois |
| 12.St. Mary’s/ Creighton | 12.Iona |
| 3.Texas Tech (San Diego) | 3.LSU (Fort Worth) |
| 14.Liberty | 14.Towson |
| 6.UConn | 6.Ohio State |
| 11.Indiana | 11.Oregon |
| 2.Wisconsin (Milwaukee) | 2.Arizona (San Diego) |
| 15.Lousiana-Lafayette | 15.UC Riverside |
| 7.Seton Hall | 7.BYU |
| 10.TCU | 10.Iowa |
| East Region (Philadelphia) | Midwest Region (Chicago) |
| 1.Kansas (Milwaukee) | 1.Baylor (Fort Worth) |
| 16.Wagner | 16.Southern/ Southeast Louisiana |
| 8.Marquette | 8.Miami |
| 9.San Diego State | 9.San Francisco |
| 4.Houston (Buffalo) | 4.Kentucky (Indianapolis) |
| 13.Lousiana Tech | 13.South Dakota State |
| 5.USC | 5.Providence |
| 12.Belmont/ Mississippi State | 12.Chattanooga |
| 3.Michigan State (Pittsburgh) | 3.Villanova (Pittsburgh) |
| 14.Oakland | 14.Vermont |
| 6.Tennessee | 6.Alabama |
| 11.Wake Forest | 11.Minnesota |
| 2.Duke (Greenville) | 2.Purdue (Indianapolis) |
| 15.Navy | 15.Princeton |
| 7.Murray State | 7.Loyola-Chicago |
| 10.Davidson | 10.West Virginia |
NIT One Seeds: Boise State, Florida, Texas A&M, Saint Louis
The Next Five: Cincinnati, Kansas State, Notre Dame, Northwestern, Virginia Tech