Bracketology by Jonathon Warriner
Updated March 5th, 2022
| West Region (San Francisco) | South Region (San Antonio) |
| 1.Gonzaga (Portland) | 1.Baylor (Fort Worth) |
| 16.Nicholls State/ Texas Southern | 16.Cleveland State/ Bryant |
| 8.TCU | 8.Seton Hall |
| 9.San Diego State | 9.San Francisco |
| 4.UCLA (San Diego) | 4.Arkansas (Portland) |
| 13.New Mexico State | 13.Northern Iowa |
| 5.Houston | 5.St. Mary’s |
| 12.Xavier/ Notre Dame | 12.Michigan/ SMU |
| 3.Texas Tech (Milwaukee) | 3.Tennessee (Pittsburgh) |
| 14.Towson | 14.Princeton |
| 6.Colorado State | 6.Ohio State |
| 11.Wyoming | 11.Wake Forest |
| 2.Wisconsin (Milwaukee) | 2.Duke (Greenville) |
| 15.Colgate | 15.Longwood |
| 7.LSU | 7.Iowa State |
| 10.North Carolina | 10.VCU |
| East Region (Philadelphia) | Midwest Region (Chicago) |
| 1.Auburn (Greenville) | 1.Arizona (San Diego) |
| 16.Norfolk State | 16.Long Beach State |
| 8.Davidson | 8.Boise State |
| 9.Creighton | 9.Marquette |
| 4.Illinois (Buffalo) | 4.Providence (Buffalo) |
| 13.Chattanooga | 13.Vermont |
| 5.UConn | 5.Texas |
| 12.South Dakota State | 12.Iona |
| 3.Villanova (Pittsburgh) | 3.Purdue (Indianapolis) |
| 14.Toledo | 14.Texas State |
| 6.Iowa | 6.Alabama |
| 11.Miami | 11.North Texas |
| 2.Kansas (Fort Worth) | 2.Kentucky (Indianapolis) |
| 15.Montana State | 15.Jacksonville State |
| 7.USC | 7.Murray State |
| 10.Memphis | 10.Michigan State |
NIT One Seeds: Rutgers, BYU, Florida, Indiana
The Next Five: Oklahoma, Oregon, Virginia Tech, Loyola-Chicago, Colorado