Bracketology by Jonathon Warriner
Updated January 19th, 2021
| West Region | South Region |
| 1.Gonzaga | 1.Baylor |
| 16.Alabama A&M/ North Dakota State | 16.Colgate/ North Carolina A&T |
| 8.Xavier | 8.Boise State |
| 9.Louisville | 9.Seton Hall |
| 4.Alabama | 4.Creighton |
| 13.Abilene Christian | 13.Western Kentucky |
| 5.Illinois | 5.USC |
| 12.Furman | 12.Syracuse/ Michigan State |
| 3.Kansas | 3.Missouri |
| 14.Siena | 14.Belmont |
| 6.Virginia | 6.Clemson |
| 11.Indiana | 11.Wichita State |
| 2.Houston | 2.Michigan |
| 15.Cal State Bakersfield | 15.Vermont |
| 7.Oregon | 7.UCLA |
| 10.Rutgers | 10.BYU |
| Midwest Region | East Region |
| 1.Texas | 1.Villanova |
| 16.Texas State | 16.Eastern Washington |
| 8.LSU | 8.Florida State |
| 9.Drake | 9.Oklahoma |
| 4.Wisconsin | 4.West Virginia |
| 13.Liberty | 13.Toledo |
| 5.Minnesota | 5.Virginia Tech |
| 12.Duke/ Arkansas | 12.Winthrop |
| 3.Ohio State | 3.Colorado |
| 14.Wright State | 14.Bryant |
| 6.Oklahoma State | 6.Texas Tech |
| 11.North Carolina | 11.Purdue |
| 2.Tennessee | 2.Iowa |
| 15.Northeastern | 15.Grand Canyon |
| 7.Uconn | 7.Saint Louis |
| 10.Maryland | 10.Pittsburgh |
NIT One Seeds: Marquette, Richmond, Florida, Utah State
The Next Five: NC State, Stanford, Northwestern, San Diego State, VCU