Bracketology by Jonathon Warriner
Updated April 6th, 2021
| West Region (San Francisco) | East Region (Philadelphia) |
| 1.Gonzaga (Portland) | 1.Michigan (Pittsburgh) |
| 16.Texas Southern/ Nicholls State | 16.Bryant/ Norfolk State |
| 8.Colorado State | 8.Auburn |
| 9.Tennessee | 9.Xavier |
| 4.Georgia Tech (Portland) | 4.Baylor (San Diego) |
| 13.Iona | 13.Colgate |
| 5.Arizona | 5.Arkansas |
| 12.Oral Roberts | 12.UC Santa Barbara |
| 3.West Virginia (Buffalo) | 3.Alabama (Fort Worth) |
| 14.Yale | 14.Liberty |
| 6.Michigan State | 6.Oregon |
| 11.Uconn | 11.Utah/ Georgia |
| 2.Villanova (Pittsburgh) | 2.Duke (Greenville) |
| 15.Winthrop | 15.Georgia State |
| 7.North Carolina | 7.Indiana |
| 10.LSU | 10.Georgetown |
| Midwest Region (Chicago) | South Region (San Antonio) |
| 1.Kansas (Milwaukee) | 1.UCLA (San Diego) |
| 16.Vermont | 16.Weber State |
| 8.Louisville | 8.Florida |
| 9.Drake | 9.Syracuse |
| 4.Florida State (Fort Worth) | 4.Houston (Milwaukee) |
| 13.Ohio | 13.Morehead State |
| 5.Saint Bonaventure | 5.Maryland |
| 12.Louisiana Tech | 12.Seton Hall/ BYU |
| 3.Ohio State (Buffalo) | 3.Virginia (Greenville) |
| 14.Furman | 14.Wright State |
| 6.Virginia Tech | 6.VCU |
| 11.Providence | 11.Illinois |
| 2.Kentucky (Indianapolis) | 2.Purdue (Indianapolis) |
| 15.Abilene Christian | 15.Northeastern |
| 7.Memphis | 7.Texas |
| 10.Saint Louis | 10.Saint John’s |
NIT One Seeds: USC, Wichita State, Oklahoma State, Stanford
The Next Five: Nevada, Oklahoma, Iowa, Creighton, Oregon State