Bracketology by Jonathon Warriner
Updated November 27th, 2021
| East Region (Philadelphia) | West Region (San Francisco) |
| 1.Duke (Greenville) | 1.Gonzaga (Portland) |
| 16.Bryant/ Norfolk State | 16.Southern Utah |
| 8.Texas Tech | 8.Washington State |
| 9.Illinois | 9.North Carolina |
| 4.St. Bonaventure (Buffalo) | 4.Seton Hall (Pittsburgh) |
| 13.UAB | 13.Belmont |
| 5.Wisconsin | 5.Michigan State |
| 12.Iona | 12.West Virginia/ UCF |
| 3.Texas (Fort Worth) | 3.Arkansas (Milwaukee) |
| 14.Georgia State | 14.Hofstra |
| 6.UConn | 6.Iowa State |
| 11.Utah State/ Santa Clara | 11.Loyola-Chicago |
| 2.Florida (Greenville) | 2.UCLA (San Diego) |
| 15.Yale | 15.Liberty |
| 7.Xavier | 7.Auburn |
| 10.San Francisco | 10.St. John’s |
| South Region (San Antonio) | Midwest Region (Chicago) |
| 1.Baylor (Fort Worth) | 1.Purdue (Indianapolis) |
| 16.Texas Southern/ Nicholls State | 16.Campbell |
| 8.Michigan | 8.USC |
| 9.St. Mary’s | 9.Florida State |
| 4.BYU (Portland) | 4.Alabama (Pittsburgh) |
| 13.South Dakota State | 13.Bufalo |
| 5.Ohio State | 5.Houston |
| 12.UC Riverside | 12.Chattanooga |
| 3.Villanova (Buffalo) | 3.Kansas (Milwaukee) |
| 14.Colgate | 14.Vermont |
| 6.Colorado State | 6.Indiana |
| 11.Cincinnati | 11.San Diego State |
| 2.Kentucky (Indianapolis) | 2.Arizona (San Diego) |
| 15.Cleveland State | 15.New Mexico State |
| 7.Memphis | 7.Tennessee |
| 10.Virginia Tech | 10.Marquette |
NIT One Seeds: Wichita State, LSU, Virginia, Providence
The Next Five: Drake, Notre Dame, Maryland, Oklahoma, Louisville