Bracketology by Jonathon Warriner
Updated November 24th, 2021
| West Region (San Francisco) | Midwest Region (Chicago) |
| 1.Gonzaga (Portland) | 1.Kansas (Milwaukee) |
| 16.Southern Utah | 16.Bryant/ Norfolk State |
| 8.Washington State | 8.Florida State |
| 9.North Carolina | 9.Drake |
| 4.Seton Hall (Buffalo) | 4.Ohio State (Buffalo) |
| 13.South Dakota State | 13.Belmont |
| 5.St. Bonaventure | 5.Arkansas |
| 12.Notre Dame/ UCF | 12.UC Riverside |
| 3.Texas (Milwaukee) | 3.Villanova (Pittsburgh) |
| 14.Iona | 14.Vermont |
| 6.Indiana | 6.Michigan |
| 11.Cincinnati/ San Francisco | 11.USC |
| 2.UCLA (San Diego) | 2.Kentucky (Indianapolis) |
| 15.Cleveland State | 15.Yale |
| 7.Tennessee | 7.Colorado State |
| 10.Santa Clara | 10.St. John’s |
| South Region (San Antonio) | East Region (Philadelphia) |
| 1.Duke (Greenville) | 1.Purdue (Indianapolis) |
| 16.Texas Southern/ Nicholls State | 16.Campbell |
| 8.UConn | 8.Virginia Tech |
| 9.Illinois | 9.Marquette |
| 4.Florida (Pittsburgh) | 4.BYU (Portland) |
| 13.UAB | 13.New Mexico State |
| 5.St. Mary’s | 5.Xavier |
| 12.Buffalo | 12.Chattanooga |
| 3.Memphis (Greenville) | 3.Arizona (San Diego) |
| 14.Colgate | 14.Georgia State |
| 6.Auburn | 6.Houston |
| 11.Loyola-Chicago | 11.Loyola-Chicago |
| 2.Baylor (Fort Worth) | 2.Alabama (Fort Worth) |
| 15.Hofstra | 15.Liberty |
| 7.Michigan State | 7.Texas Tech |
| 10.Oregon | 10.Wisconsin |
NIT One Seeds: West Virginia, Utah State, Wichita State, LSU
The Next Five: Virginia, Providence, Mississippi State, Oklahoma, Louisville