Bracketology by Jonathon Warriner
Updated June 10th, 2021
| West Region (San Francisco) | Midwest Region (Chicago) |
| 1.Gonzaga (Portland) | 1.Villanova (Pittsburgh) |
| 16.Northeastern | 16.Bryant/ Norfolk State |
| 8.Arizona | 8.Oklahoma State |
| 9.San Diego State | 9.Michigan State |
| 4.Arkansas (San Diego) | 4.Florida State (Buffalo) |
| 13.UC Santa Barbara | 13.Belmont |
| 5.Maryland | 5.Auburn |
| 12.Oral Roberts | 12.Iona |
| 3.Baylor (Fort Worth) | 3.North Carolina (Greenville) |
| 14.Grand Canyon | 14.Furman |
| 6.Indiana | 6.Colorado State |
| 11.USC | 11.Butler |
| 2.UCLA (San Diego) | 2.Purdue (Indianapolis) |
| 15.Northern Colorado | 15.Winthrop |
| 7.Tennessee | 7.Virginia |
| 10.Seton Hall | 10.Kansas State |
| East Region (Philadelphia) | South Region (San Antonio) |
| 1.Duke (Greenville) | 1.Kansas (Milwaukee) |
| 16.Yale | 16.Texas Southern/ New Orleans |
| 8.Illinois | 8.Syracuse |
| 9.Florida | 9.Drake |
| 4.Texas (Buffalo) | 4.Oregon (Portland) |
| 13.Colgate | 13.Liberty |
| 5.Houston | 5.Memphis |
| 12.Ohio | 12.VCU/ Mississippi State |
| 3.Alabama (Fort Worth) | 3.Ohio State (Milwaukee) |
| 14.Milwaukee | 14.UAB |
| 6.Saint Bonaventure | 6.Virginia Tech |
| 11.Oklahoma | 11.Nevada/ Washington State |
| 2.Michigan (Pittsburgh) | 2.Kentucky (Indianapolis) |
| 15.Vermont | 15.Georgia State |
| 7.BYU | 7.Xavier |
| 10.Wichita State | 10.Georgia Tech |
NIT One Seeds: Wisconsin, Saint Louis, West Virginia, LSU
The Next Five: Providence, Colorado, Texas Tech, Rutgers, Utah