Bracketology by Jonathon Warriner
Updated February 21st, 2022
| West Region (San Francisco) | Midwest Region (Chicago) |
| 1.Gonzaga (Portland) | 1.Auburn (Greenville) |
| 16.Southern/ Liberty | 16.Colgate/ Nicholls State |
| 8.Wyoming | 8.Davidson |
| 9.Iowa | 9.Seton Hall |
| 4.Texas (Portland) | 4.Providence (Buffalo) |
| 13.South Dakota State | 13.Ohio |
| 5.USC | 5.Houston |
| 12.North Carolina/ Rutgers | 12.Loyola-Chicago |
| 3.Wisconsin (Pittsburgh) | 3.Texas Tech (Milwaukee) |
| 14.Vermont | 14.Towson |
| 6.Arkansas | 6.LSU |
| 11.Notre Dame | 11.San Diego State |
| 2.Duke (Greenville) | 2.Purdue (Indianapolis) |
| 15.Norfolk State | 15.Yale |
| 7.Marquette | 7.Colorado State |
| 10.TCU | 10.Creighton |
| East Region (Philadelphia) | South Region (San Antonio) |
| 1.Kansas (Fort Worth) | 1.Arizona (San Diego) |
| 16.Longwood | 16.Long Beach State |
| 8.Xavier | 8.St. Mary’s |
| 9.Wake Forest | 9.Boise State |
| 4.UCLA (San Diego) | 4.Tennessee (Buffalo) |
| 13.New Mexico State | 13.Chattanooga |
| 5.Alabama | 5.Ohio State |
| 12.North Texas | 12.Iona |
| 3.Villanova (Pittsburgh) | 3.Illinois (Milwaukee) |
| 14.Oakland | 14.Wagner |
| 6.Murray State | 6.UConn |
| 11.Michigan/ Memphis | 11.SMU |
| 2.Kentucky (Indianapolis) | 2.Baylor (Fort Worth) |
| 15.Montana State | 15.Texas State |
| 7.Iowa State | 7.Michigan State |
| 10.Miami | 10.San Francisco |
NIT One Seeds: Indiana, BYU, Florida, Oregon
The Next Five: Belmont, Kansas State, VCU, Dayton, Oklahoma