Bracketology by Jonathon Warriner
Updated December 1st, 2021
| Midwest Region (Chicago) | West Region (San Francisco) |
| 1.Purdue (Indianapolis) | 1.Gonzaga (Portland) |
| 16.Texas Southern/ Nicholls State | 16.Southern Utah |
| 8.Texas Tech | 8.Illinois |
| 9.San Francisco | 9.Virginia Tech |
| 4.BYU (Portland) | 4.Alabama (Buffalo) |
| 13.South Dakota State | 13.UAB |
| 5.Seton Hall | 5.Houston |
| 12.UC Riverside | 12.Iona |
| 3.Kansas (Milwaukee) | 3.Arkansas (Fort Worth) |
| 14.Liberty | 14.Georgia State |
| 6.Xavier | 6.Colorado State |
| 11.Louisville | 11.Loyola-Chicago |
| 2.Kentucky (Indianapolis) | 2.Arizona (San Diego) |
| 15.Yale | 15.Cleveland State |
| 7.St. Bonaventure | 7.Tennessee |
| 10.St. John’s | 10.Indiana |
| South Region (San Antonio) | East Region (Philadelphia) |
| 1.Baylor (Fort Worth) | 1.Duke (Greenville) |
| 16.Campbell | 16.Bryant/ Norfolk State |
| 8.St. Mary’s | 8.USC |
| 9.North Carolina | 9.Iowa |
| 4.Wisconsin (Pittsburgh) | 4.Texas (Milwaukee) |
| 13.Buffalo | 13.Belmont |
| 5.UConn | 5.Michigan State |
| 12.Chattanooga | 12.Virginia/ San Diego State |
| 3.Villanova (Buffalo) | 3.Ohio State (Pittsburgh) |
| 14.Vermont | 14.Colgate |
| 6.Memphis | 6.Iowa State |
| 11.Oklahoma/ Florida State | 11.Utah State |
| 2.Florida (Greenville) | 2.UCLA (San Diego) |
| 15.Hofstra | 15.New Mexico State |
| 7.Michigan | 7.Auburn |
| 10.LSU | 10.Marquette |
NIT One Seeds: Wichita State, Virginia, Providence, Washington State
The Next Five: UCF, TCU, Oregon, Maryland, Creighton