Bracketology by Jonathon Warriner
Updated March 13th, 2021
| West Region | South Region |
| 1.Gonzaga | 1.Baylor |
| 16.Appalachain State/ Norfolk State | 16.Oral Roberts |
| 8.Wisconsin | 8.San Diego State |
| 9.Florida | 9.Rutgers |
| 4.Purdue | 4.Virginia |
| 13.Liberty | 13.Toledo |
| 5.Colorado | 5.Villanova |
| 12.Syracuse/ Utah State | 12.Winthrop |
| 3.Texas | 3.Arkansas |
| 14.UNC Greensboro | 14.Morehead State |
| 6.USC | 6.Texas Tech |
| 11.Maryland | 11.Colorado State |
| 2.Ohio State | 2.Iowa |
| 15.Cleveland State | 15.Iona |
| 7.Missouri | 7.Oklahoma |
| 10.Georgia Tech | 10.VCU |
| East Region | Midwest Region |
| 1.Illinois | 1.Michigan |
| 16.Prairie View A&M/ Mount Saint Mary’s | 16.Hartford |
| 8.Oregon | 8.Uconn |
| 9.Saint Bonaventure | 9.North Carolina |
| 4.West Virginia | 4.Florida State |
| 13.UC Santa Barbara | 13.Colgate |
| 5.Creighton | 5.Tennessee |
| 12.UCLA/ Drake | 12.Western Kentucky |
| 3.Kansas | 3.Houston |
| 14.Grand Canyon | 14.Abeline Christian |
| 6.BYU | 6.Clemson |
| 11.Wichita State | 11.Louisville |
| 2.Alabama | 2.Oklahoma State |
| 15.Drexel | 15.Eastern Washington |
| 7.Loyola-Chicago | 7.LSU |
| 10.Michigan State | 10.Virginia Tech |
NIT One Seeds: Ole Miss, Saint Louis, Boise State, Saint John’s
Others Considered: Memphis, Xavier