Bracketology by Jonathon Warriner
Updated November 13th, 2021
| Midwest Region (Chicago) | West Region (San Francisco) |
| 1.Kansas (Milwaukee) | 1.Gonzaga (Portland) |
| 16.Bryant/ Norfolk State | 16.Texas Southern/ Nicholls State |
| 8.Drake | 8.Arizona |
| 9.Uconn | 9.Indiana |
| 4.North Carolina (Buffalo) | 4.Illinois (Buffalo) |
| 13.UAB | 13.Iona |
| 5.Auburn | 5.Saint Bonaventure |
| 12.San Diego State/ Oklahoma | 12.Furman |
| 3.Villanova (Pittsburgh) | 3.Oregon (Portland) |
| 14.Colgate | 14.South Dakota State |
| 6.Tennessee | 6.Houston |
| 11.Syracuse | 11.Kansas State/ Rutgers |
| 2.Purdue (Indianapolis) | 2.Alabama (Fort Worth) |
| 15.Winthrop | 15.Hofstra |
| 7.Texas Tech | 7.Maryland |
| 10.USC | 10.Butler |
| South Region (San Antonio) | East Region (Philadelphia) |
| 1.UCLA (San Diego) | 1.Duke (Greenville) |
| 16.Southern Utah | 16.Yale |
| 8.Virginia Tech | 8.Michigan State |
| 9.Florida | 9.St. John’s |
| 4.Kentucky (Greenville) | 4.Arkansas (San Diego) |
| 13.Belmont | 13.New Mexico State |
| 5.Florida State | 5.Seton Hall |
| 12.Buffalo | 12.UC Riverside |
| 3.Memphis (Milwaukee) | 3.Baylor (Indianapolis) |
| 14.Liberty | 14.Cleveland State |
| 6.Ohio State | 6.BYU |
| 11.Loyola-Chicago | 11.Providence |
| 2.Texas (Fort Worth) | 2.Michigan (Pittsburgh) |
| 15.Louisiana Lafayette | 15.Vermont |
| 7.Colorado State | 7.Xavier |
| 10.Washington State | 10.West Virginia |
NIT One Seeds: Notre Dame, Wisconsin, Ole Miss, Wichita State
The Next Five: LSU, San Francisco, Mississippi State, TCU, St. Mary’s