Bracketology by Jonathon Warriner
Updated November 14th, 2021
| West Region (San Francisco) | Midwest Region (Chicago) |
| 1.Gonzaga (Portland) | 1.Kansas (Milwaukee) |
| 16.Texas Southern/ Nicholls State | 16.Bryant/ Norfolk State |
| 8.Florida State | 8.Drake |
| 9.UConn | 9.Indiana |
| 4.Illinois (Buffalo) | 4.Kentucky (Buffalo) |
| 13.Iona | 13.UAB |
| 5.Saint Bonaventure | 5.Houston |
| 12.Furman | 12.San Diego State/ UCF |
| 3.Oregon (Portland) | 3.Villanova (Pittsburgh) |
| 14.South Dakota State | 14.Colgate |
| 6.Tennessee | 6.BYU |
| 11.Kansas State/ Rutgers | 11.Loyola-Chicago |
| 2.Baylor (Fort Worth) | 2.Purdue (Indianapolis) |
| 15.Hofstra | 15.Winthrop |
| 7.Maryland | 7.Colorado State |
| 10.Butler | 10.West Virginia |
| South Region (San Antonio) | East Region (Philadelphia) |
| 1.UCLA (San Diego) | 1.Duke (Greenville) |
| 16.Southern Utah | 16.Yale |
| 8.Virginia Tech | 8.Arizona |
| 9.Michigan State | 9.St. John’s |
| 4.North Carolina (Greenville) | 4.Arkansas (San Diego) |
| 13.Belmont | 13.New Mexico State |
| 5.Auburn | 5.Seton Hall |
| 12.Buffalo | 12.UC Riverside |
| 3.Memphis (Milwaukee) | 3.Texas (Indianapolis) |
| 14.Liberty | 14.Cleveland State |
| 6.Ohio State | 6.Florida |
| 11.Syracuse | 11.Providence |
| 2.Alabama (Fort Worth) | 2.Michigan (Pittsburgh) |
| 15.Louisiana Lafayette | 15.Vermont |
| 7.Texas Tech | 7.Xavier |
| 10.Washington State | 10.USC |
NIT One Seeds: Oklahoma, Notre Dame, Wisconsin, Ole Miss
The Next Five: LSU, Wichita State, San Francisco, Mississippi State, TCU