Bracketology by Jonathon Warriner
Updated April 30th, 2021
| Midwest Region (Chicago) | East Region (Philadelphia) |
| 1.Michigan (Indianapolis) | 1.Villanova (Pittsburgh) |
| 16.Texas Southern/ New Orleans | 16.Bryant/ Norfolk State |
| 8.Drake | 8.Michigan State |
| 9.VCU | 9.TCU |
| 4.Texas (Milwaukee) | 4.Houston (Portland) |
| 13.Belmont | 13.Liberty |
| 5.Virginia | 5.Auburn |
| 12.Oral Roberts | 12.USC/ Nevada |
| 3.North Carolina (Greenville) | 3.Ohio State (Pittsburgh) |
| 14.UAB | 14.Furman |
| 6.Indiana | 6.Saint Bonaventure |
| 11.LSU | 11.Louisville/ Uconn |
| 2.Alabama (Fort Worth) | 2.Duke (Greenville) |
| 15.Georgia State | 15.Winthrop |
| 7.Oregon | 7.Tennessee |
| 10.Oklahoma State | 10.Kansas State |
| West Region (San Francisco) | South Region (San Antonio) |
| 1.Gonzaga (Portland) | 1.Kansas (Milwaukee) |
| 16.Weber State | 16.Yale |
| 8.Seton Hall | 8.Illinois |
| 9.Arizona | 9.BYU |
| 4.Baylor (San Diego) | 4.Kentucky (Buffalo) |
| 13.UC Santa Barbara | 13.Colgate |
| 5.Maryland | 5.Memphis |
| 12.Ohio | 12.Iona |
| 3.Florida State (Buffalo) | 3.Arkansas (Fort Worth) |
| 14.Vermont | 14.Grand Canyon |
| 6.Xavier | 6.Virginia Tech |
| 11.Mississippi State | 11.Georgetown |
| 2.UCLA (San Diego) | 2.Purdue (Indianapolis) |
| 15.Northeastern | 15.Cleveland State |
| 7.Colorado State | 7.Syracuse |
| 10.Saint Louis | 10.Florida |
NIT One Seeds: Georgia Tech, San Diego State, Washington State, Oklahoma
The Next Five: Providence, Wichita State, Utah, St. John’s, Arizona State