Bracketology by Jonathon Warriner
Updated February 12th, 2022
| South Region (San Antonio) | West Region (San Francisco) |
| 1.Auburn (Greenville) | 1.Gonzaga (Portland) |
| 16.Appalachain State/ Colgate | 16.Long Beach State |
| 8.Seton Hall | 8.Colorado State |
| 9.Davidson | 9.Iowa State |
| 4.Marquette (Buffalo) | 4.Tennessee (Portland) |
| 13.Ohio | 13.South Dakota State |
| 5.Michigan State | 5.Ohio State |
| 12.Iona | 12.Creighton/ SMU |
| 3.Wisconsin (Milwaukee) | 3.Texas Tech (Milwaukee) |
| 14.Cleveland State | 14.Liberty |
| 6.Wyoming | 6.Xavier |
| 11.Loyola-Chicago | 11.Miami |
| 2.Baylor (Fort Worth) | 2.Arizona (San Diego) |
| 15.Longwood | 15.Montana State |
| 7.USC | 7.Murray State |
| 10.Wake Forest | 10.Indiana |
| East Region (Philadelphia) | Midwest Region (Chicago) |
| 1.Kentucky (Indianapolis) | 1.Kansas (Fort Worth) |
| 16.UNC Wilmington | 16.Southern/ New Orleans |
| 8.Boise State | 8.St. Mary’s |
| 9.TCU | 9.Iowa |
| 4.Illinois (Pittsburgh) | 4.UCLA (San Diego) |
| 13.North Texas | 13.New Mexico State |
| 5.Texas | 5.Houston |
| 12.Chattanooga | 12.North Carolina/ BYU |
| 3.Villanova (Pittsburgh) | 3.Providence (Buffalo) |
| 14.Wagner | 14.Vermont |
| 6.LSU | 6.Arkansas |
| 11.Oklahoma | 11.Notre Dame |
| 2.Duke (Greenville) | 2.Purdue (Indianapolis) |
| 15.Yale | 15.Norfolk State |
| 7.Alabama | 7.UConn |
| 10.Michigan | 10.Oregon |
NIT One Seeds: San Diego State, Belmont, San Francisco, West Virginia
The Next Five: Florida, Mississippi State, Rutgers, Kansas State, Stanford