Bracketology by Jonathon Warriner
Updated January 11th, 2022
| South Region (San Antonio) | Midwest Region (Chicago) |
| 1.Baylor (Fort Worth) | 1.Auburn (Greenville) |
| 16.Southern/ Southeast Louisiana | 16.Campbell |
| 8.Colorado State | 8.Oklahoma |
| 9.North Carolina | 9.Belmont |
| 4.UCLA (Portland) | 4.Villanova (Pittsburgh) |
| 13.South Dakota State | 13.UAB |
| 5.Ohio State | 5.Iowa State |
| 12.Saint Mary’s/ Florida | 12.Chattanooga |
| 3.USC (San Diego) | 3.Michigan State (Pittsburgh) |
| 14.New Mexico State | 14.Vermont |
| 6.UConn | 6.Tennessee |
| 11.Memphis/ TCU | 11.Creighton |
| 2.Purdue (Indianapolis) | 2.Kansas (Milwaukee) |
| 15.Princeton | 15.Louisiana-Lafayette |
| 7.Kentucky | 7.BYU |
| 10.Davidson | 10.Indiana |
| East Region (Philadelphia) | West Region (San Francisco) |
| 1.LSU (Fort Worth) | 1.Arizona (San Diego) |
| 16.St. Francis (PA)/ Norfolk State | 16.Northern Colorado |
| 8.Texas | 8.San Francisco |
| 9.Miami | 9.San Diego State |
| 4.Seton Hall (Buffalo) | 4.Alabama (Buffalo) |
| 13.Ohio | 13.Oakland |
| 5.Houston | 5.Illinois |
| 12.Murray State | 12.Iona |
| 3.Duke (Greenville) | 3.Xavier (Indianapolis) |
| 14.Navy | 14.Hofstra |
| 6.Providence | 6.Texas Tech |
| 11.Minnesota | 11.Wake Forest |
| 2.Wisconsin (Milwaukee) | 2.Gonzaga (Portland) |
| 15.Liberty | 15.UC Irvine |
| 7.Loyola-Chicago | 7.Oklahoma |
| 10.Marquette | 10.Iowa |
NIT One Seeds: Virginia Tech, Texas A&M, UCF, Saint Louis
The Next Five: Clemson, Michigan, Louisville, Utah State, Mississippi State