Bracketology by Jonathon Warriner
Updated February 24th, 2022
| West Region (San Francisco) | Midwest Region (Chicago) |
| 1.Gonzaga (Portland) | 1.Auburn (Greenville) |
| 16.Texas Southern/ New Orleans | 16.Colgate/ UNC Wilmington |
| 8.Wyoming | 8.Seton Hall |
| 9.Creighton | 9.Davidson |
| 4.Texas (Portland) | 4.Providence (Buffalo) |
| 13.South Dakota State | 13.Vermont |
| 5.Houston | 5.Ohio State |
| 12.North Carolina/ San Diego State | 12.Iona |
| 3.Wisconsin (Pittsburgh) | 3.Texas Tech (Milwaukee) |
| 14.Princeton | 14.Texas State |
| 6.Arkansas | 6.USC |
| 11.SMU | 11.Michigan |
| 2.Duke (Greenville) | 2.Purdue (Indianapolis) |
| 15.Norfolk State | 15.Liberty |
| 7.Iowa | 7.LSU |
| 10.TCU | 10.Wake Forest |
| East Region (Philadelphia) | South Region (San Antonio) |
| 1.Kansas (Fort Worth) | 1.Arizona (San Diego) |
| 16.Clevaland State | 16.Long Beach State |
| 8.Michigan State | 8.St. Mary’s |
| 9.Xavier | 9.Boise State |
| 4.UCLA (San Diego) | 4.Tennessee (Buffalo) |
| 13.New Mexico State | 13.Chattanooga |
| 5.Alabama | 5.UConn |
| 12.North Texas | 12.Loyola-Chicago |
| 3.Villanova (Pittsburgh) | 3.Illinois (Milwaukee) |
| 14.Ohio | 14.Wagner |
| 6.Murray State | 6.Colorado State |
| 11.Memphis/ VCU | 11.Notre Dame |
| 2.Kentucky (Indianapolis) | 2.Baylor (Fort Worth) |
| 15.Longwood | 15.Montana State |
| 7.Iowa State | 7.Marquette |
| 10.Miami | 10.San Francisco |
NIT One Seeds: BYU, Indiana, Rutgers, Oregon
The Next Five: Florida, Belmont, Dayton, Virginia Tech, Kansas State