Bracketology by Jonathon Warriner
Updated July 9th, 2021
| West Region (San Francisco) | South Region (San Antonio) |
| 1.Gonzaga (Portland) | 1.Kansas (Milwaukee) |
| 16.Weber State | 16.Texas Southern/ New Orleans |
| 8.Syracuse | 8.Illinois |
| 9.Michigan State | 9.Drake |
| 4.Houston (San Diego) | 4.Arkansas (Milwaukee) |
| 13.UC Santa Barbara | 13.Liberty |
| 5.Ohio State | 5.St. Bonaventure |
| 12.Washington State/ Seton Hall | 12.Buffalo |
| 3.Texas (Fort Worth) | 3.Oregon (Portland) |
| 14.Grand Canyon | 14.UAB |
| 6.Indiana | 6.BYU |
| 11.Wichita State | 11.West Virginia/ Butler |
| 2.UCLA (San Diego) | 2.Duke (Greenville) |
| 15.Northern Colorado | 15.Georgia State |
| 7.Colorado State | 7.Texas Tech |
| 10.Rutgers | 10.Florida |
| Midwest Region (Chicago) | East Region (Philadelphia) |
| 1.Kentucky (Indianapolis) | 1.Villanova (Pittsburgh) |
| 16.Yale | 16.Bryant/ Norfolk State |
| 8.Maryland | 8.Arizona |
| 9.San Diego State | 9.Oklahoma State |
| 4.Baylor (Buffalo) | 4.Florida State (Buffalo) |
| 13.Colgate | 13.Belmont |
| 5.Memphis | 5.Auburn |
| 12.Oral Roberts | 12.Iona |
| 3.Alabama (Fort Worth) | 3.North Carolina (Greenville) |
| 14.Milwaukee | 14.Furman |
| 6.Virginia Tech | 6.Tennessee |
| 11.USC | 11.Nevada |
| 2.Michigan (Pittsburgh) | 2.Purdue (Indianapolis) |
| 15.Vermont | 15.Winthrop |
| 7.Xavier | 7.Virginia |
| 10.LSU | 10.St. John’s |
NIT One Seeds: Kansas State, Mississippi State, VCU, Wisconsin
The Next Five: Providence, Colorado, Louisville, Notre Dame, Utah