Bracketology by Jonathon Warriner
Updated December 29th, 2021
| South Region (San Antonio) | East Region (Philadelphia) |
| 1.Baylor (Fort Worth) | 1.Duke (Greenville) |
| 16.Nicholls State/ Texas Southern | 16.Campbell |
| 8.BYU | 8.Texas |
| 9.Wake Forest | 9.Iowa |
| 4.UCLA (San Diego) | 4.Houston (Buffalo) |
| 13.New Mexico State | 13.Iona |
| 5.Xavier | 5.Villanova |
| 12.Florida/ TCU | 12.UAB |
| 3.Ohio State (Pittsburgh) | 3.Tennessee (Greenville) |
| 14.Vermont | 14.Navy |
| 6.UConn | 6.Texas Tech |
| 11.St. Mary’s | 11.Marquette |
| 2.Auburn (Fort Worth) | 2.Michigan State (Pittsburgh) |
| 15.South Alabama | 15.Liberty |
| 7.Illinois | 7.West Virginia |
| 10.Belmont | 10.Davidson |
| Midwest Region (Chicago) | West Region (San Francisco) |
| 1.Purdue (Indianapolis) | 1.Gonzaga (Portland) |
| 16.Norfolk State/ Bryant | 16.Southern Utah |
| 8.Loyola-Chicago | 8.Minnesota |
| 9.Virginia Tech | 9.Oklahoma |
| 4.USC (Portland) | 4.Providence (Buffalo) |
| 13.Oakland | 13.Hofstra |
| 5.Alabama | 5.Wisconsin |
| 12.Memphis/ Indiana | 12.Chattanooga |
| 3.LSU (Indianapolis) | 3.Iowa State (Milwaukee) |
| 14.Ohio | 14.South Dakota State |
| 6.Seton Hall | 6.Kentucky |
| 11.North Carolina | 11.Michigan |
| 2.Kansas (Milwaukee) | 2.Arizona (San Diego) |
| 15.Princeton | 15.UC Irvine |
| 7.Colorado State | 7.San Francisco |
| 10.Creighton | 10.Utah State |
NIT One Seeds: UCF, DePaul, San Diego State, Cincinnati
The Next Five: Clemson, Northwestern, Mississippi State, Saint Louis, Kansas State