Bracketology by Jonathon Warriner
Updated January 14th, 2022
| South Region (San Antonio) | Midwest Region (Chicago) |
| 1.Baylor (Fort Worth) | 1.Auburn (Greenville) |
| 16.Southern/ Southeast Louisiana | 16.Gardner-Webb/ Norfolk State |
| 8.BYU | 8.West Virginia |
| 9.Belmont | 9.Marquette |
| 4.Xavier (Buffalo) | 4.USC (San Diego) |
| 13.Oakland | 13.New Mexico State |
| 5.Alabama | 5.Illinois |
| 12.Chattanooga | 12.Texas A&M/ St. Mary’s |
| 3.Villanova (Pittsburgh) | 3.Michigan State (Pittsburgh) |
| 14.Vermont | 14.Wagner |
| 6.Ohio State | 6.Kentucky |
| 11.Minnesota | 11.Creighton |
| 2.Purdue (Indianapolis) | 2.Kansas (Milwaukee) |
| 15.Louisiana-Lafayette | 15.Liberty |
| 7.San Francisco | 7.Seton Hall |
| 10.TCU | 10.Miami |
| East Region (Philadelphia) | West Region (San Francisco) |
| 1.LSU (Fort Worth) | 1.Gonzaga (Portland) |
| 16.Drexel | 16.Weber State |
| 8.Oklahoma | 8.Colorado State |
| 9.North Carolina | 9.San Diego State |
| 4.Iowa State (Portland) | 4.Houston (Buffalo) |
| 13.Ohio | 13.South Dakota State |
| 5.UCLA | 5.Providence |
| 12.Iona | 12.Murray State |
| 3.Duke (Greenville) | 3.Texas Tech (Indianapolis) |
| 14.Navy | 14.Louisiana Tech |
| 6.Tennessee | 6.UConn |
| 11.Indiana | 11.Wake Forest / Oregon |
| 2.Wisconsin (Milwaukee) | 2.Arizona (San Diego) |
| 15.Princeton | 15.UC Davis |
| 7.Loyola-Chicago | 7.Texas |
| 10.Davidson | 10.Iowa |
NIT One Seeds: Stanford, Boise State, Memphis, UCF
The Next Five: Florida, Michigan, Mississippi State, Saint Louis, Notre Dame