Bracketology by Jonathon Warriner
Updated February 6th, 2022
| South Region (San Antonio) | West Region (San Francisco) |
| 1.Auburn (Greenville) | 1.Gonzaga (Portland) |
| 16.Appalachain State/ Longwood | 16.Hawaii |
| 8.Davidson | 8.Wyoming |
| 9.Indiana | 9.TCU |
| 4.Illinois (Pittsburgh) | 4.Marquette (Buffalo) |
| 13.South Dakota State | 13.Toledo |
| 5.UCLA | 5.LSU |
| 12.Chattanooga | 12.Iona |
| 3.Texas Tech (Milwaukee) | 3.Wisconsin (Milwaukee) |
| 14.Oakland | 14.Wagner |
| 6.Xavier | 6.Texas |
| 11.Loyola-Chicago | 11.Creighton |
| 2.Duke (Greenville) | 2.Arizona (San Diego) |
| 15.Norfolk State | 15.Weber State |
| 7.UConn | 7.St. Mary’s |
| 10.Iowa | 10.Arkansas |
| East Region (Philadelphia) | Midwest Region (Chicago) |
| 1.Baylor (Fort Worth) | 1.Kansas (Fort Worth) |
| 16.Navy | 16.Southern/ New Orleans |
| 8.Murray State | 8.Seton Hall |
| 9.San Francisco | 9.Colorado State |
| 4.Ohio State (Portland) | 4.Houston (San Diego) |
| 13.New Mexico State | 13.North Texas |
| 5.Tennessee | 5.Michigan State |
| 12.Notre Dame/ San Diego State | 12.Florida/ Saint Louis |
| 3.Providence (Buffalo) | 3.Villanova (Pittsburgh) |
| 14.Vermont | 14.Princeton |
| 6.USC | 6.Alabama |
| 11.Miami | 11.BYU |
| 2.Kentucky (Indianapolis) | 2.Purdue (Indianapolis) |
| 15.UNC Greensboro | 15.Jacksonville State |
| 7.Iowa State | 7.Boise State |
| 10.Wake Forest | 10.Oregon |
NIT One Seeds: Oklahoma, Mississippi State, North Carolina, Belmont
The Next Five: West Virginia, Stanford, SMU, Florida State, Washington State