Bracketology by Jonathon Warriner
Updated December 12th, 2021
| South Region (San Antonio) | West Region (San Francisco) |
| 1.Baylor (Fort Worth) | 1.Arizona (San Diego) |
| 16.Texas Southern/ Nicholls State | 16.Weber State |
| 8.Tennessee | 8.BYU |
| 9.St. Mary’s | 9.Minnesota |
| 4.Xavier (Indianapolis) | 4.Iowa State (Portland) |
| 13.Ohio | 13.South Dakota State |
| 5.Wisconsin | 5.Colorado State |
| 12.Belmont | 12.UC Irvine |
| 3.UCLA (San Diego) | 3.Michigan State (Pittsburgh) |
| 14.Navy | 14.Northeastern |
| 6.Kentucky | 6.North Carolina |
| 11.Utah State/ DePaul | 11.Loyola-Chicago |
| 2.Alabama (Fort Worth) | 2.Gonzaga (Portland) |
| 15.Georgia State | 15.Utah Valley |
| 7.Texas Tech | 7.Illinois |
| 10.Wake Forest | 10.Creighton |
| Midwest Region (Chicago) | East Region (Philadelphia) |
| 1.Purdue (Indianapolis) | 1.Duke (Greenville) |
| 16.Norfolk State/ Bryant | 16.Harvard |
| 8.Florida | 8.Providence |
| 9.St. Bonaventure | 9.Oklahoma |
| 4.Seton Hall (Buffalo) | 4.LSU (Greenville) |
| 13.Iona | 13.UAB |
| 5.Texas | 5.UConn |
| 12.Chattanooga | 12.Iowa/ West Virginia |
| 3.Houston (Milwaukee) | 3.Ohio State (Pittsburgh) |
| 14.Oakland | 14.Vermont |
| 6.Auburn | 6.USC |
| 11.Michigan | 11.St. John’s |
| 2.Kansas (Milwaukee) | 2.Villanova (Buffalo) |
| 15.Liberty | 15.Campbell |
| 7.San Francisco | 7.Arkansas |
| 10.Marquette | 10.Indiana |
NIT One Seeds: Northwestern, Kansas State, Florida State, Wichita State
The Next Five: UCF, Cincinnati, San Diego State, Louisville, TCU