Bracketology by Jonathon Warriner
Updated December 19th, 2021
| South Region (San Antonio) | West Region (San Francisco) |
| 1.Baylor (Fort Worth) | 1.Arizona (San Diego) |
| 16.Nicholls State/ Wagner | 16.Texas Southern |
| 8.BYU | 8.Oklahoma |
| 9.Wake Forest | 9.San Francisco |
| 4.Wisconsin (San Diego) | 4.Alabama (Portland) |
| 13.UC Irvine | 13.New Mexico State |
| 5.USC | 5.Villanova |
| 12.UAB | 12.Utah State/ Saint Mary’s |
| 3.Ohio State (Pittsburgh) | 3.Iowa State (Milwaukee) |
| 14.Ohio | 14.South Dakota State |
| 6.Kentucky | 6.UConn |
| 11.TCU | 11.Indiana |
| 2.Xavier (Indianapolis) | 2.Gonzaga (Portland) |
| 15.Campbell | 15.Weber State |
| 7.Illinois | 7.Texas |
| 10.DePaul | 10.Michigan |
| Midwest Region (Chicago) | East Region (Philadelphia) |
| 1.Purdue (Indianapolis) | 1.Duke (Greenville) |
| 16.Norfolk State/ Charleston | 16.Liberty |
| 8.Loyola-Chicago | 8.West Virginia |
| 9.Belmont | 9.Creighton |
| 4.Seton Hall (Buffalo) | 4.Providence (Buffalo) |
| 13.Iona | 13.Oakland |
| 5.Auburn | 5.UCLA |
| 12.Chattanooga | 12.Davidson |
| 3.Houston (Fort Worth) | 3.Michigan State (Pittsburgh) |
| 14.South Alabama | 14.Navy |
| 6.Tennessee | 6.Colorado State |
| 11.Iowa | 11.Marquette/ Arkansas |
| 2.Kansas (Milwaukee) | 2.LSU (Greenville) |
| 15.Vermont | 15.Princeton |
| 7.Minnesota | 7.Texas Tech |
| 10.Virginia Tech | 10.North Carolina |
NIT One Seeds: Cincinnati, Florida, Memphis, UCF
The Next Five: San Diego State, Mississippi State, Wichita State, Wyoming