Bracketology by Jonathon Warriner
Updated January 30th, 2022
| South Region (San Antonio) | Midwest Region (Chicago) |
| 1.Auburn (Greenville) | 1.Baylor (Fort Worth) |
| 16.Liberty/ Longwood | 16.Southern/ Texas A&M CC |
| 8.Davidson | 8.Colorado State |
| 9.Oklahoma | 9.St. Mary’s |
| 4.Michigan State (Pittsburgh) | 4.Alabama (Buffalo) |
| 13.UAB | 13.Ohio |
| 5.Xavier | 5.Marquette |
| 12.Chattanooga | 12.Wake Forest/ West Virginia |
| 3.UCLA (San Diego) | 3.Villanova (Pittsburgh) |
| 14.Seattle | 14.Vermont |
| 6.Illinois | 6.Tennessee |
| 11.Mississippi State | 11.Wyoming |
| 2.Kansas (Milwaukee) | 2.Wisconsin (Milwaukee) |
| 15.Arkansas State | 15.UNC Wilmington |
| 7.Indiana | 7.USC |
| 10.Arkansas | 10.TCU |
| East Region (Philadelphia) | West Region (San Francisco) |
| 1.Purdue (Indianapolis) | 1.Gonzaga (Portland) |
| 16.Navy | 16.Cal State Fullerton |
| 8.Miami | 8.Boise State |
| 9.Loyola-Chicago | 9.Seton Hall |
| 4.Providence (Buffalo) | 4.Houston (Portland) |
| 13.Oakland | 13.South Dakota State |
| 5.LSU | 5.Iowa State |
| 12.Iona | 12.San Francisco/ San Diego State |
| 3.Duke (Greenville) | 3.Texas Tech (Fort Worth) |
| 14.Princeton | 14.Wagner |
| 6.UConn | 6.Ohio State |
| 11.Florida | 11.Oregon |
| 2.Kentucky (Indianapolis) | 2.Arizona (San Diego) |
| 15.Norfolk State | 15.Weber State |
| 7.Murray State | 7.Texas |
| 10.Iowa | 10.BYU |
NIT One Seeds:North Carolina, Belmont, SMU, VCU
The Next Five: Creighton, Florida State, Texas A&M, Notre Dame, Stanford