Bracketology by Jonathon Warriner
Updated December 6th, 2021
| Midwest Region (Chicago) | |
| 1.Purdue (Indianapolis) | East Region (Philadelphia) |
| 16.Norfolk State/ Bryant | 1.Duke (Greenville) |
| 8.Oklahoma | 16.Harvard |
| 9.Providence | 8.Auburn |
| 4.Villanova (Buffalo) | 9.Michigan |
| 13.Iona | 4.Michigan State (Buffalo) |
| 5.Houston | 13.UAB |
| 12.Belmont | 5.Seton Hall |
| 3.Florida (Greenville) | 12.Wake Forest/ Washington State |
| 14.Navy | 3.Ohio State (Pittsburgh) |
| 6.Xavier | 14.Vermont |
| 11.Utah State | 6.Iowa State |
| 2.Kansas (Milwaukee) | 11.Marquette/ Syracuse |
| 15.Liberty | 2.Kentucky (Indianapolis) |
| 7.St. Bonaventure | 15.Campbell |
| 10.Indiana | 7.USC |
| 10.Texas Tech | |
| West Region (San Francisco) | |
| 1.Arizona (San Diego) | South Region (San Antonio) |
| 16.Weber State | 1.Baylor (Fort Worth) |
| 8.San Francisco | 16.Texas Southern/ Nicholls State |
| 9.Iowa | 8.LSU |
| 4.Texas (Portland) | 9.St. Mary’s |
| 13.South Dakota State | 4.Wisconsin (Pittsburgh) |
| 5.Colorado State | 13.Ohio |
| 12.UC Irvine | 5.UConn |
| 3.Arkansas (Milwaukee) | 12.Chattanooga |
| 14.Northeastern | 3.UCLA (San Diego) |
| 6.North Carolina | 14.Oakland |
| 11.Loyola-Chicago | 6.BYU |
| 2.Gonzaga (Portland) | 11.Louisville |
| 15.Utah Valley | 2.Alabama (Fort Worth) |
| 7.Tennessee | 15.Georgia State |
| 10.Kansas State | 7.Illinois |
| 10.St. John’s |
NIT One Seeds: Wichita State, Ole Miss, Florida State, Cincinnati
The Next Five: TCU, UCF, San Diego State, Minnesota, Virginia