Bracketology by Jonathon Warriner
Updated December 4th, 2021
| Midwest Region (Chicago) | West Region (San Francisco) |
| 1.Purdue (Indianapolis) | 1.Gonzaga (Portland) |
| 16.Harvard | 16.Weber State |
| 8.Oklahoma | 8.LSU |
| 9.San Francisco | 9.Virginia Tech |
| 4.Alabama (Portland) | 4.Michigan State (Buffalo) |
| 13.South Dakota State | 13.UAB |
| 5.Colorado State | 5.UConn |
| 12.UC Irvine | 12.Belmont |
| 3.Florida (Greenville) | 3.Arkansas (Fort Worth) |
| 14.Navy | 14.Oakland |
| 6.Xavier | 6.North Carolina |
| 11.Memphis/ Florida State | 11.Texas Tech |
| 2.Kansas (Milwaukee) | 2.Arizona (San Diego) |
| 15.Georgia State | 15.Liberty |
| 7.St. Bonaventure | 7.Tennessee |
| 10.Indiana | 10.Marquette |
| South Region (San Antonio) | East Region (Philadelphia) |
| 1.Baylor (Fort Worth) | 1.Duke (Greenville) |
| 16.Texas Southern/ Nicholls State | 16.Bryant/ Norfolk State |
| 8.Auburn | 8.Illinois |
| 9.Iowa | 9.St. John’s |
| 4.Wisconsin (Pittsburgh) | 4.Texas (Milwaukee) |
| 13.Iona | 13.Ohio |
| 5.Houston | 5.Seton Hall |
| 12.Chattanooga | 12.Wichita State/ Louisville |
| 3.Villanova (Buffalo) | 3.Ohio State (Pittsburgh) |
| 14.Vermont | 14.Northeastern |
| 6.Iowa State | 6.BYU |
| 11.Loyola-Chicago | 11.Providence |
| 2.Kentucky (Indianapolis) | 2.UCLA (San Diego) |
| 15.Campbell | 15.Utah Valley |
| 7.USC | 7.St. Mary’s |
| 10.Michigan | 10.Utah State |
NIT One Seeds: Virginia, Washington State, TCU, Saint Louis
The Next Five: Oregon, Creighton, NC State, Cincinnati, Kansas State