Bracketology by Jonathon Warriner
Updated February 18th, 2022
| South Region (San Antonio) | West Region (San Francisco) |
| 1.Auburn (Greenville) | 1.Gonzaga (Portland) |
| 16.Nicholls State/ Colgate | 16.Long Beach State |
| 8.TCU | 8.Wyoming |
| 9.Seton Hall | 9.Iowa |
| 4.Illinois (Buffalo) | 4.UCLA (San Diego) |
| 13.South Dakota State | 13.North Texas |
| 5.Texas | 5.Michigan State |
| 12.Iona | 12.Chattanooga |
| 3.Villanova (Pittsburgh) | 3.Tennessee (Pittsburgh) |
| 14.Oakland | 14.Wagner |
| 6.Alabama | 6.Colorado State |
| 11.Michigan | 11.Memphis |
| 2.Baylor (Fort Worth) | 2.Wisconsin (Greenville) |
| 15.Texas State | 15.Norfolk State |
| 7.St. Mary’s | 7.Arkansas |
| 10.Miami | 10.Davidson |
| East Region (Philadelphia) | Midwest Region (Chicago) |
| 1.Kansas (Fort Worth) | 1.Arizona (San Diego) |
| 16.Longwood | 16.Southern/ Liberty |
| 8.Xavier | 8.Iowa State |
| 9.Loyola-Chicago | 9.Boise State |
| 4.Providence (Buffalo) | 4.Ohio State (Portland) |
| 13.Ohio | 13.New Mexico State |
| 5.LSU | 5.Houston |
| 12.Kansas State/ Indiana | 12.Creighton/ BYU |
| 3.Duke (Greenville) | 3.Texas Tech (Milwaukee) |
| 14.Vermont | 14.Towson |
| 6.Marquette | 6.USC |
| 11.Notre Dame | 11.Rutgers |
| 2.Purdue (Indianapolis) | 2.Kentucky (Indianapolis) |
| 15.Yale | 15.Montana State |
| 7.Murray State | 7.UConn |
| 10.San Francisco | 10.Wake Forest |
NIT One Seeds: Oklahoma, San Diego State, North Carolina, Oregon
The Next Five: SMU, Belmont, Stanford, Dayton, West Virginia