Bracketology by Jonathon Warriner
Updated December 5th, 2021
| Midwest Region (Chicago) | East Region (Philadelphia) |
| 1.Purdue (Indianapolis) | 1.Duke (Greenville) |
| 16.Norfolk State/ Bryant | 16.Harvard |
| 8.Oklahoma | 8.Auburn |
| 9.Providence | 9.Michigan |
| 4.Villanova (Buffalo) | 4.Michigan State (Buffalo) |
| 13.Iona | 13.UAB |
| 5.Houston | 5.Seton Hall |
| 12.Belmont | 12.Wake Forest/ Wichita State |
| 3.Florida (Greenville) | 3.Ohio State (Pittsburgh) |
| 14.Navy | 14.Vermont |
| 6.Xavier | 6.Iowa State |
| 11.Kansas State/ Syracuse | 11.Loyola-Chicago |
| 2.Kansas (Milwaukee) | 2.Kentucky (Indianapolis) |
| 15.Liberty | 15.Campbell |
| 7.St. Bonaventure | 7.USC |
| 10.Indiana | 10.Texas Tech |
| West Region (San Francisco) | South Region (San Antonio) |
| 1.Arizona (San Diego) | 1.Baylor (Fort Worth) |
| 16.Weber State | 16.Texas Southern/ Nicholls State |
| 8.San Francisco | 8.LSU |
| 9.Iowa | 9.St. Mary’s |
| 4.Texas (Portland) | 4.Wisconsin (Pittsburgh) |
| 13.South Dakota State | 13.Ohio |
| 5.Colorado State | 5.UConn |
| 12.UC Irvine | 12.Chattanooga |
| 3.Arkansas (Milwaukee) | 3.UCLA (San Diego) |
| 14.Northeastern | 14.Oakland |
| 6.North Carolina | 6.BYU |
| 11.Marquette | 11.Louisville |
| 2.Gonzaga (Portland) | 2.Alabama (Fort Worth) |
| 15.Utah Valley | 15.Georgia State |
| 7.Tennessee | 7.Illinois |
| 10.Utah State | 10.St. John’s |
NIT One Seeds: Washington State, Ole Miss, Oregon, Cincinnati
The Next Five: Florida State, TCU, UCF, San Diego State, Mississippi State