Bracketology by Jonathon Warriner
Updated February 11th, 2022
| South Region (San Antonio) | West Region (San Francisco) |
| 1.Auburn (Greenville) | 1.Gonzaga (Portland) |
| 16.Appalachain State/ Longwood | 16.Hawaii |
| 8.Seton Hall | 8.Colorado State |
| 9.Davidson | 9.Iowa State |
| 4.Marquette (Buffalo) | 4.Tennessee (Portland) |
| 13.Toledo | 13.South Dakota State |
| 5.Michigan State | 5.Texas |
| 12.Iona | 12.Creighton/ SMU |
| 3.Wisconsin (Milwaukee) | 3.Texas Tech (Milwaukee) |
| 14.Oakland | 14.Princeton |
| 6.Wyoming | 6.LSU |
| 11.Loyola-Chicago | 11.Miami |
| 2.Baylor (Fort Worth) | 2.Arizona (San Diego) |
| 15.Jacksonville State | 15.Weber State |
| 7.USC | 7.Boise State |
| 10.Wake Forest | 10.Indiana |
| East Region (Philadelphia) | Midwest Region (Chicago) |
| 1.Kentucky (Indianapolis) | 1.Kansas (Fort Worth) |
| 16.Navy | 16.Southern/ New Orleans |
| 8.Murray State | 8.St. Mary’s |
| 9.TCU | 9.Iowa |
| 4.Illinois (Pittsburgh) | 4.UCLA (San Diego) |
| 13.Chattanooga | 13.New Mexico State |
| 5.UConn | 5.Houston |
| 12.UAB | 12.San Diego State/ BYU |
| 3.Villanova (Pittsburgh) | 3.Providence (Buffalo) |
| 14.Wagner | 14.Vermont |
| 6.Ohio State | 6.Arkansas |
| 11.Oklahoma | 11.Notre Dame |
| 2.Duke (Greenville) | 2.Purdue (Indianapolis) |
| 15.UNC Greensboro | 15.Norfolk State |
| 7.Alabama | 7.Xavier |
| 10.Michigan | 10.Oregon |
NIT One Seeds: Saint Louis, Belmont, San Francisco, West Virginia
The Next Five: Florida, North Carolina, Mississippi State, Rutgers, Utah State