Bracketology by Jonathon Warriner
Updated November 9th, 2021
| West Region (San Francisco) | Midwest Region (Chicago) |
| 1.Gonzaga (Portland) | 1.Kansas (Milwaukee) |
| 16.Southern Utah | 16.Nicholls State/ Norfolk State |
| 8.Arizona | 8.Indiana |
| 9.Michigan State | 9.St. John’s |
| 4.Alabama (San Diego) | 4.Arkansas (Buffalo) |
| 13.New Mexico State | 13.Iona |
| 5.St. Bonaventure | 5.Florida State |
| 12.Louisiana Tech | 12.Belmont |
| 3.Baylor (Fort Worth) | 3.Villanova (Pittsburgh) |
| 14.Cleveland State | 14.Colgate |
| 6.Colorado State | 6.Tennessee |
| 11.Loyola-Chicago | 11.Kansas State |
| 2.UCLA (San Diego) | 2.Purdue (Indianapolis) |
| 15.Stony Brook | 15.Northeastern |
| 7.Xavier | 7.BYU |
| 10.Virginia | 10.Butler |
| South Region (San Antonio) | East Region (Philadelphia) |
| 1.Michigan (Pittsburgh) | 1.Kentucky (Indianapolis) |
| 16.Yale | 16.Bryant/ Texas Southern |
| 8.Virginia Tech | 8.Drake |
| 9.Florida | 9.Rutgers |
| 4.Illinois (San Diego) | 4.Oregon (Portland) |
| 13.UC Riverside | 13.Liberty |
| 5.Houston | 5.Ohio State |
| 12.Louisville/ West Virginia | 12.Buffalo |
| 3.North Carolina (Greenville) | 3.Memphis (Milwaukee) |
| 14.Chattanooga | 14.South Dakota State |
| 6.Auburn | 6.Maryland |
| 11.USC | 11.Nevada/ Richmond |
| 2.Texas (Fort Worth) | 2.Duke (Greenville) |
| 15.Louisiana Lafayette | 15.Winthrop |
| 7.Seton Hall | 7.Texas Tech |
| 10.Washington State | 10.UConn |
NIT One Seeds: San Diego State, Syracuse, Wisconsin, Providence
The Next Five: Oklahoma, Ole Miss, Wichita State, Missouri State, San Francisco