Bracketology by Jonathon Warriner
Updated December 8th, 2021
| Midwest Region (Chicago) | East Region (Philadelphia) |
| 1.Purdue (Indianapolis) | 1.Duke (Greenville) |
| 16.Norfolk State/ Bryant | 16.Harvard |
| 8.Tennessee | 8.Texas Tech |
| 9.Providence | 9.Michigan |
| 4.Houston (Greenville) | 4.Michigan State (Buffalo) |
| 13.UAB | 13.Iona |
| 5.Iowa State | 5.Seton Hall |
| 12.Belmont | 12.Oklahoma/ Washington State |
| 3.Villanova (Buffalo) | 3.Ohio State (Pittsburgh) |
| 14.Navy | 14.Vermont |
| 6.LSU | 6.Xavier |
| 11.Louisville | 11.Wake Forest |
| 2.Kansas (Milwaukee) | 2.Kentucky (Indianapolis) |
| 15.Liberty | 15.Campbell |
| 7.Auburn | 7.St. Bonaventure |
| 10.Indiana | 10.St. John’s |
| West Region (San Francisco) | South Region (San Antonio) |
| 1.Arizona (San Diego) | 1.Baylor (Fort Worth) |
| 16.Weber State | 16.Texas Southern/ Nicholls State |
| 8.San Francisco | 8.Florida |
| 9.Iowa | 9.St. Mary’s |
| 4.Texas (Portland) | 4.Wisconsin (Pittsburgh) |
| 13.South Dakota State | 13.Ohio |
| 5.Colorado State | 5.UConn |
| 12.UC Irvine | 12.Chattanooga |
| 3.Arkansas (Milwaukee) | 3.UCLA (San Diego) |
| 14.Northeastern | 14.Oakland |
| 6.North Carolina | 6.BYU |
| 11.Loyola-Chicago | 11.Marquette/ Wyoming |
| 2.Gonzaga (Portland) | 2.Alabama (Fort Worth) |
| 15.Utah Valley | 15.Georgia State |
| 7.Illinois | 7.USC |
| 10.Utah State | 10.Kansas State |
NIT One Seeds: Ole Miss, Cincinnati, Florida State, Wichita State
The Next Five: UCF, Minnesota, Syracuse, San Diego State, Creighton