Bracketology by Jonathon Warriner
Updated November 12th, 2021
| Midwest Region (Chicago) | West Region (San Francisco) |
| 1.Kansas (Milwaukee) | 1.Gonzaga (Portland) |
| 16.Nicholls State/ Norfolk State | 16.Southern Utah |
| 8.Drake | 8.Arizona |
| 9.Uconn | 9.Indiana |
| 4.Arkansas (Buffalo) | 4.Kentucky (San Diego) |
| 13.Chattanooga | 13.New Mexico State |
| 5.St. Bonaventure | 5.Seton Hall |
| 12.Iona | 12.UC Riverside |
| 3.Alabama (Indianapolis) | 3.Baylor (Fort Worth) |
| 14.Colgate | 14.Cleveland State |
| 6.Houston | 6.Colorado State |
| 11.Richmond/ Rutgers | 11.Louisville |
| 2.Purdue (Indianapolis) | 2.UCLA (San Diego) |
| 15.Northeastern | 15.Winthrop |
| 7.Xavier | 7.Maryland |
| 10.Washington State | 10.Nevada |
| South Region (San Antonio) | East Region (Philadelphia) |
| 1.Michigan (Pittsburgh) | 1.Duke (Greenville) |
| 16.Yale | 16.Bryant/ Texas Southern |
| 8.Virginia Tech | 8.Michigan State |
| 9.Florida | 9.St. John’s |
| 4.Oregon (San Diego) | 4.Illinois (Buffalo) |
| 13.Louisiana Tech | 13.Belmont |
| 5.Florida State | 5.Auburn |
| 12.Buffalo | 12.San Diego State/ Syracuse |
| 3.North Carolina (Greenville) | 3.Memphis (Milwaukee) |
| 14.Liberty | 14.South Dakota State |
| 6.Tennessee | 6.Ohio State |
| 11.Loyola-Chicago | 11.West Virginia |
| 2.Texas (Fort Worth) | 2.Villanova (Pittsburgh) |
| 15.Louisiana Lafayette | 15.Vermont |
| 7.BYU | 7.Texas Tech |
| 10.Butler | 10.USC |
NIT One Seeds: Kansas State, Wisconsin, Providence, Oklahoma
The Next Five: Ole Miss, Wichita State, Mississippi State, Notre Dame, San Francisco