Bracketology by Jonathon Warriner
Updated December 25th, 2021
| South Region (San Antonio) | East Region (Philadelphia) |
| 1.Baylor (Fort Worth) | 1.Duke (Greenville) |
| 16.Nicholls State/ Texas Southern | 16.Campbell |
| 8.Iowa | 8.Texas Tech |
| 9.Creighton | 9.Davidson |
| 4.Seton Hall (Buffalo) | 4.Ohio State (Pittsburgh) |
| 13.Iona | 13.Hofstra |
| 5.Wisconsin | 5.Villanova |
| 12.Chattanooga | 12.UAB |
| 3.Michigan State (Pittsburgh) | 3.Providence (Buffalo) |
| 14.Ohio | 14.Vermont |
| 6.Xavier | 6.Alabama |
| 11.TCU | 11.Michigan |
| 2.Auburn (Fort Worth) | 2.Tennessee (Greenville) |
| 15.South Alabama | 15.Liberty |
| 7.West Virginia | 7.Wake Forest |
| 10.North Carolina | 10.DePaul |
| Midwest Region (Chicago) | West Region (San Francisco) |
| 1.Purdue (Indianapolis) | 1.Gonzaga (Portland) |
| 16.Norfolk State/ Bryant | 16.Southern Utah |
| 8.Loyola-Chicago | 8.Illinois |
| 9.Texas | 9.Oklahoma |
| 4.USC (San Diego) | 4.Houston (Portland) |
| 13.New Mexico State | 13.Oakland |
| 5.UConn | 5.UCLA |
| 12.BYU/ St. Mary’s | 12.Memphis/ Belmont |
| 3.LSU (Indianapolis) | 3.Iowa State (Milwaukee) |
| 14.Navy | 14.South Dakota State |
| 6.Minnesota | 6.Colorado State |
| 11.Murray State | 11.Indiana |
| 2.Kansas (Milwaukee) | 2.Arizona (San Diego) |
| 15.Princeton | 15.UC Irvine |
| 7.Kentucky | 7.San Francisco |
| 10.Virginia Tech | 10.Utah State |
NIT One Seeds: Marquette, Louisville, Cincinnati, Kansas State
The Next Five: Arkansas, Northwestern, UCF, Saint Louis, Mississippi State