Bracketology by Jonathon Warriner
Updated January 4th, 2022
| South Region (San Antonio) | East Region (Philadelphia) |
| 1.Baylor (Fort Worth) | 1.Duke (Greenville) |
| 16.Nicholls State/ Texas Southern | 16.Norfolk State/ St. Francis (PA) |
| 8.Loyola-Chicago | 8.Texas Tech |
| 9.North Carolina | 9.Belmont |
| 4.Tennessee (Greenville) | 4.LSU (Portland) |
| 13.Hofstra | 13.South Dakota State |
| 5.Houston | 5.UCLA |
| 12.UAB | 12.Michigan/ SMU |
| 3.USC (San Diego) | 3.Purdue (Indianapolis) |
| 14.New Mexico State | 14.Vermont |
| 6.UConn | 6.Colorado State |
| 11.Florida | 11.Wake Forest/ UCF |
| 2.Wisconsin (Milwaukee) | 2.Providence (Buffalo) |
| 15.Liberty | 15.Princeton |
| 7.Texas | 7.Minnesota |
| 10.St. Mary’s | 10.Davidson |
| Midwest Region (Chicago) | West Region (San Francisco) |
| 1.Auburn (Fort Worth) | 1.Arizona (San Diego) |
| 16.Campbell | 16.Southern Utah |
| 8.Illinois | 8.Iowa |
| 9.Oklahoma | 9.BYU |
| 4.Villanova (Buffalo) | 4.Xavier (Pittsburgh) |
| 13.Iona | 13.Oakland |
| 5.Ohio State | 5.Alabama |
| 12.Murray State | 12.Chattanooga |
| 3.Michigan State (Pittsburgh) | 3.Iowa State (Indianapolis) |
| 14.Navy | 14.Ohio |
| 6.Seton Hall | 6.Kentucky |
| 11.TCU | 11.San Diego State |
| 2.Kansas (Milwaukee) | 2.Gonzaga (Portland) |
| 15.South Alabama | 15.UC Irvine |
| 7.San Francisco | 7.West Virginia |
| 10.Virginia Tech | 10.Creighton |
NIT One Seeds: Memphis, Louisville, Saint Louis, Utah State
The Next Five: Texas A&M, Miami, Northwestern, Mississippi State, Clemson