Bracketology by Jonathon Warriner
Updated March 14th, 2021
| West Region | South Region |
| 1.Gonzaga | 1.Baylor |
| 16.Texas Southern/ Norfolk State | 16.Oral Roberts |
| 8.Uconn | 8.Wisconsin |
| 9.Georgia Tech | 9.Saint Bonaventure |
| 4.Purdue | 4.Florida State |
| 13.Colgate | 13.Abilene Christian |
| 5.USC | 5.Villanova |
| 12.Georgetown | 12.UC Santa Barbara |
| 3.Kansas | 3.Arkansas |
| 14.Eastern Washington | 14.Morehead State |
| 6.LSU | 6.Texas Tech |
| 11.UCLA/ Louisville | 11.Syracuse |
| 2.Iowa | 2.Ohio State |
| 15.Grand Canyon | 15.Drexel |
| 7.Clemson | 7.Loyola-Chicago |
| 10.VCU | 10.Virginia Tech |
| East Region | Midwest Region |
| 1.Michigan | 1.Illinois |
| 16.Appalachain State/ Hartford | 16.Mount Saint Mary’s |
| 8.Oklahoma | 8.San Diego State |
| 9.Florida | 9.North Carolina |
| 4.Virginia | 4.West Virginia |
| 13.North Texas | 13.Ohio |
| 5.Creighton | 5.Tennessee |
| 12.Winthrop | 12.Oregon State |
| 3.Oklahoma State | 3.Texas |
| 14.UNC Greensboro | 14.Liberty |
| 6.BYU | 6.Colorado |
| 11.Wichita State/ Drake | 11.Michigan State |
| 2.Alabama | 2.Houston |
| 15.Cleveland State | 15.Iona |
| 7.Oregon | 7.Missouri |
| 10.Maryland | 10.Rutgers |
NIT One Seeds: Utah State, Colorado State, Ole Miss, Saint Louis