Bracketology by Jonathon Warriner
Updated November 21st, 2021
| West Region (San Francisco) | Midwest Region (Chicago) |
| 1.Gonzaga (Portland) | 1.Kansas (Milwaukee) |
| 16.Texas Southern/ Nicholls State | 16.Bryant/ Norfolk State |
| 8.Florida State | 8.Virginia Tech |
| 9.UConn | 9.Drake |
| 4.Florida (Buffalo) | 4.BYU (Portland) |
| 13.UAB | 13.South Dakota State |
| 5.Saint Bonaventure | 5.Auburn |
| 12.Furman | 12.UC Riverside |
| 3.Kentucky (Greenville) | 3.Memphis (Milwaukee) |
| 14.Colgate | 14.Iona |
| 6.Oregon | 6.Xavier |
| 11.Oklahoma | 11.Kansas State |
| 2.Baylor (Fort Worth) | 2.Purdue (Indianapolis) |
| 15.Liberty | 15.Cleveland State |
| 7.Ohio State | 7.Colorado State |
| 10.Providence | 10.St. John’s |
| South Region (San Antonio) | East Region (Philadelphia) |
| 1.UCLA (San Diego) | 1.Duke (Greenville) |
| 16.Southern Utah | 16.Campbell |
| 8.Tennessee | 8.Michigan State |
| 9.Marquette | 9.Washington State |
| 4.Michigan (Pittsburgh) | 4.Arkansas (San Diego) |
| 13.Belmont | 13.New Mexico State |
| 5.North Carolina | 5.Houston |
| 12.Buffalo | 12.UCF/ San Francisco |
| 3.Alabama (Fort Worth) | 3.Texas (Indianapolis) |
| 14.Georgia State | 14.Vermont |
| 6.Indiana | 6.Illinois |
| 11.Notre Dame/ Santa Clara | 11.Loyola-Chicago |
| 2.Villanova (Pittsburgh) | 2.Seton Hall (Buffalo) |
| 15.Hofstra | 15.Yale |
| 7.Texas Tech | 7.Arizona |
| 10.USC | 10.San Diego State |
NIT One Seeds: West Virginia, LSU, Maryland, Wichita State
The Next Five: Chattanooga, Mississippi State, TCU, Louisville, Creighton