Bracketology by Jonathon Warriner
Updated January 24th, 2021
| West Region | South Region |
| 1.Gonzaga | 1.Baylor |
| 16.Alabama A&M/ North Dakota State | 16.Colgate/ North Carolina A&T |
| 8.Louisville | 8.UCLA |
| 9.Uconn | 9.Drake |
| 4.Texas Tech | 4.Wisconsin |
| 13.Abilene Christian | 13.Western Kentucky |
| 5.Minnesota | 5.Florida State |
| 12.Winthrop | 12.Furman |
| 3.Illinois | 3.Ohio State |
| 14.Bryant | 14.Siena |
| 6.West Virginia | 6.Colorado |
| 11.Stanford | 11.LSU |
| 2.Houston | 2.Alabama |
| 15.Cal State Bakersfield | 15.Vermont |
| 7.Oklahoma | 7.Saint Louis |
| 10.Xavier | 10.North Carolina |
| Midwest Region | East Region |
| 1.Texas | 1.Michigan |
| 16.Eastern Washington | 16.Texas State |
| 8.Virginia Tech | 8.Clemson |
| 9.Rutgers | 9.Oregon |
| 4.Creighton | 4.Kansas |
| 13.Toledo | 13.Liberty |
| 5.Purdue | 5.Virginia |
| 12.Utah State/ Arkansas | 12.San Diego State/ Wichita State |
| 3.Missouri | 3.Tennessee |
| 14.Belmont | 14.Wright State |
| 6.Boise State | 6.Oklahoma State |
| 11.Maryland | 11.Indiana |
| 2.Iowa | 2.Villanova |
| 15.Grand Canyon | 15.Northeastern |
| 7.USC | 7.BYU |
| 10.Seton Hall | 10.Florida |
NIT One Seeds: Pittsburgh, Michigan State, Saint Bonaventure, Syracuse
The Next Five: VCU, Georgia Tech, Providence, Colorado State, SMU