Bracketology by Jonathon Warriner
Updated December 21st, 2021
| South Region (San Antonio) | West Region (San Francisco) |
| 1.Baylor (Fort Worth) | 1.Arizona (San Diego) |
| 16.Nicholls State/ Texas Southern | 16.Weber State |
| 8.Illinois | 8.San Francisco |
| 9.Virginia Tech | 9.Texas |
| 4.Houston (Portland) | 4.Providence (Buffalo) |
| 13.Grand Canyon | 13.Davidson |
| 5.UCLA | 5.Wisconsin |
| 12.TCU/ Saint Mary’s | 12.UAB |
| 3.USC (San Diego) | 3.Iowa State (Milwaukee) |
| 14.Towson | 14.Ohio |
| 6.Colorado State | 6.Minnesota |
| 11.Indiana | 11.DePaul |
| 2.Auburn (Greenville) | 2.Gonzaga (Portland) |
| 15.South Alabama | 15.UC Irvine |
| 7.West Virginia | 7.Wake Forest |
| 10.Creighton | 10.Utah State |
| Midwest Region (Chicago) | East Region (Philadelphia) |
| 1.Purdue (Indianapolis) | 1.Duke (Greenville) |
| 16.Norfolk State/ St. Francis (PA) | 16.Campbell |
| 8.Loyola-Chicago | 8.Texas Tech |
| 9.Oklahoma | 9.Iowa |
| 4.Seton Hall (Buffalo) | 4.Ohio State (Pittsburgh) |
| 13.Navy | 13.Oakland |
| 5.Tennessee | 5.Alabama |
| 12.Monmouth | 12.Chattanooga |
| 3.LSU (Fort Worth) | 3.Michigan State (Pittsburgh) |
| 14.South Dakota State | 14.Vermont |
| 6.UConn | 6.Villanova |
| 11.Memphis/ Michigan | 11.North Carolina |
| 2.Kansas (Milwaukee) | 2.Xavier (Indianapolis) |
| 15.Liberty | 15.Princeton |
| 7.BYU | 7.Kentucky |
| 10.Marquette | 10.Murray State |
NIT One Seeds: Belmont, Louisville, Cincinnati, Wyoming
The Next Five: Kansas State, Arkansas, Northwestern Wyoming, UCF