Bracketology by Jonathon Warriner
Updated November 17th, 2021
| West Region (San Francisco) | Midwest Region (Chicago) |
| 1.Gonzaga (Portland) | 1.Kansas (Milwaukee) |
| 16.Texas Southern/ Nicholls State | 16.Bryant/ Norfolk State |
| 8.Virginia Tech | 8.Florida State |
| 9.Michigan State | 9.UConn |
| 4.Michigan (Buffalo) | 4.BYU (Portland) |
| 13.Iona | 13.UAB |
| 5.Florida | 5.Houston |
| 12.Furman | 12.San Diego State/ Santa Clara |
| 3.Kentucky (Greenville) | 3.Villanova (Pittsburgh) |
| 14.South Dakota State | 14.Colgate |
| 6.Oregon | 6.Tennessee |
| 11.Kansas State/ Marquette | 11.Loyola-Chicago |
| 2.Baylor (Fort Worth) | 2.Purdue (Indianapolis) |
| 15.Hofstra | 15.Winthrop |
| 7.Maryland | 7.Texas Tech |
| 10.Washington State | 10.Butler |
| South Region (San Antonio) | East Region (Philadelphia) |
| 1.UCLA (San Diego) | 1.Duke (Greenville) |
| 16.Southern Utah | 16.Yale |
| 8.Drake | 8.Arizona |
| 9.Indiana | 9.St. John’s |
| 4.North Carolina (Pittsburgh) | 4.Arkansas (San Diego) |
| 13.Belmont | 13.New Mexico State |
| 5.Auburn | 5.St. Bonaventure |
| 12.Buffalo | 12.UC Riverside |
| 3.Memphis (Milwaukee) | 3.Texas (Indianapolis) |
| 14.Liberty | 14.Cleveland State |
| 6.Ohio State | 6.Illinois |
| 11.Syracuse | 11.Providence |
| 2.Alabama (Fort Worth) | 2.Seton Hall (Buffalo) |
| 15.Louisiana Lafayette | 15.Vermont |
| 7.Xavier | 7.Colorado State |
| 10.USC | 10.West Virginia |
NIT One Seeds: Rutgers, Oklahoma, Notre Dame, Ole Miss
The Next Five: LSU, Wichita State, San Francisco, Mississippi State, TCU