Bracketology by Jonathon Warriner
Updated March 7th, 2022
| West Region (San Francisco) | South Region (San Antonio) |
| 1.Gonzaga (Portland) | 1.Baylor (Fort Worth) |
| 16.Jacksonville/ Bryant | 16.Texas Southern/ Nicholls |
| 8.Iowa State | 8.Seton Hall |
| 9.San Diego State | 9.Marquette |
| 4.UCLA (San Diego) | 4.Arkansas (Portland) |
| 13.New Mexico state | 13.Vermont |
| 5.Texas | 5.St. Mary’s |
| 12.Notre Dame/ Wyoming | 12.South Dakota State |
| 3.Tennessee (Pittsburgh) | 3.Wisconsin (Milwaukee) |
| 14.Princeton | 14.Montana State |
| 6.Murray State | 6.Colorado State |
| 11.Michigan | 11.Xavier |
| 2.Purdue (Indianapolis) | 2.Duke (Greenville) |
| 15.Colgate | 15.Norfolk State |
| 7.North Carolina | 7.LSU |
| 10.Memphis | 10.Davidson |
| East Region (Philadelphia) | Midwest Region (Chicago) |
| 1.Auburn (Greenville) | 1.Arizona (San Diego) |
| 16.Cleveland State | 16.Long Beach State |
| 8.Michigan State | 8.Boise State |
| 9.TCU | 9.San Francisco |
| 4.Illinois (Buffalo) | 4.Providence (Buffalo) |
| 13.Chattanooga | 13.Iona |
| 5.UConn | 5.Houston |
| 12.Wake Forest/ SMU | 12.North Texas |
| 3.Villanova (Pittsburgh) | 3.Texas Tech (Milwaukee) |
| 14.Towson | 14.Toledo |
| 6.Iowa | 6.Ohio State |
| 11.VCU | 11.Creighton |
| 2.Kansas (Fort Worth) | 2.Kentucky (Indianapolis) |
| 15.Georgia State | 15.Longwood |
| 7.Alabama | 7.USC |
| 10.Loyola-Chicago | 10.Miami |
NIT One Seeds: Rutgers, Indiana, Oklahoma, Florida
Others in Consideration: BYU, Oregon, Dayton