Bracketology by Jonathon Warriner
Updated December 30th, 2021
| South Region (San Antonio) | East Region (Philadelphia) |
| 1.Baylor (Fort Worth) | 1.Duke (Greenville) |
| 16.Nicholls State/ Texas Southern | 16.Campbell |
| 8.BYU | 8.Minnesota |
| 9.Iowa | 9.Davidson |
| 4.Houston (Indianapolis) | 4.UCLA (Portland) |
| 13.Oakland | 13.New Mexico State |
| 5.Villanova | 5.LSU |
| 12.Mississippi State/ Indiana | 12.UCF/ TCU |
| 3.Ohio State (Pittsburgh) | 3.Providence (Buffalo) |
| 14.Vermont | 14.Navy |
| 6.Seton Hall | 6.Texas Tech |
| 11.Indiana | 11.Marquette |
| 2.Auburn (Fort Worth) | 2.Michigan State (Pittsburgh) |
| 15.South Alabama | 15.Liberty |
| 7.Colorado State | 7.West Virginia |
| 10.North Carolina | 10.Creighton |
| Midwest Region (Chicago) | West Region (San Francisco) |
| 1.Purdue (Indianapolis) | 1.Gonzaga (Portland) |
| 16.Norfolk State/ Bryant | 16.Southern Utah |
| 8.Loyola-Chicago | 8.Texas |
| 9.Oklahoma | 9.Virginia Tech |
| 4.Tennessee (Greenville) | 4.Alabama (Buffalo) |
| 13.Hofstra | 13.Iona |
| 5.Xavier | 5.Wisconsin |
| 12.UAB | 12.Chattanooga |
| 3.USC (San Diego) | 3.Iowa State (Milwaukee) |
| 14.South Dakota State | 14.Ohio |
| 6.UConn | 6.Kentucky |
| 11.St. Mary’s | 11.Wake Forest |
| 2.Kansas (Milwaukee) | 2.Arizona (San Diego) |
| 15.Princeton | 15.UC Irvine |
| 7.Illinois | 7.San Francisco |
| 10.Belmont | 10.Michigan |
NIT One Seeds: Louisville, San Diego State, Cincinnati, Clemson
The Next Five: Northwestern, Saint Louis, Richmond, Kansas State, Miami