Bracketology by Jonathon Warriner
Updated December 10th, 2021
| South Region (San Antonio) | East Region (Philadelphia) |
| 1.Baylor (Fort Worth) | 1.Duke (Greenville) |
| 16.Texas Southern/ Nicholls State | 16.Harvard |
| 8.Florida | 8.Texas Tech |
| 9.St. Mary’s | 9.Michigan |
| 4.Ohio State (Pittsburgh) | 4.Michigan State (Buffalo) |
| 13.Ohio | 13.Iona |
| 5.Xavier | 5.Texas |
| 12.Chattanooga | 12.Cincinnati/ Kansas State |
| 3.UCLA (San Diego) | 3.Wisconsin (Pittsburgh) |
| 14.Oakland | 14.Vermont |
| 6.BYU | 6.UConn |
| 11.Utah State | 11.West Virginia/ Wake Forest |
| 2.Alabama (Fort Worth) | 2.Kentucky (Indianapolis) |
| 15.Georgia State | 15.Campbell |
| 7.USC | 7.St. Bonaventure |
| 10.Indiana | 10.St. John’s |
| West Region (San Francisco) | Midwest Region (Chicago) |
| 1.Arizona (San Diego) | 1.Purdue (Indianapolis) |
| 16.Weber State | 16.Norfolk State/ Bryant |
| 8.San Francisco | 8.Tennessee |
| 9.Marquette | 9.Providence |
| 4.Seton Hall (Portland) | 4.Houston (Greenville) |
| 13.South Dakota State | 13.UAB |
| 5.Colorado State | 5.Iowa State |
| 12.UC Irvine | 12.Belmont |
| 3.Arkansas (Milwaukee) | 3.Villanova (Buffalo) |
| 14.Northeastern | 14.Navy |
| 6.North Carolina | 6.LSU |
| 11.Loyola-Chicago | 11.Iowa |
| 2.Gonzaga (Portland) | 2.Kansas (Milwaukee) |
| 15.Utah Valley | 15.Liberty |
| 7.Illinois | 7.Auburn |
| 10.Wake Forest | 10.Louisville |
NIT One Seeds: Oklahoma, Ole Miss, Florida State, Wichita State
The Next Five: UCF, Syracuse, San Diego State, Creighton, Northwestern