Bracketology by Jonathon Warriner
Updated November 25th, 2021
| West Region (San Francisco) | Midwest Region (Chicago) |
| 1.Gonzaga (Portland) | 1.Kansas (Milwaukee) |
| 16.Southern Utah | 16.Bryant/ Norfolk State |
| 8.Washington State | 8.Michigan |
| 9.Illinois | 9.North Carolina |
| 4.Texas (Milwaukee) | 4.St. Bonaventure (Buffalo) |
| 13.South Dakota State | 13.Belmont |
| 5.UConn | 5.Houston |
| 12.Buffalo | 12.Chattanooga |
| 3.Florida (Pittsburgh) | 3.Villanova (Pittsburgh) |
| 14.Iona | 14.Vermont |
| 6.Ohio State | 6.Michigan State |
| 11.Loyola-Chicago | 11.San Diego State |
| 2.UCLA (San Diego) | 2.Kentucky (Indianapolis) |
| 15.Cleveland State | 15.Yale |
| 7.Tennessee | 7.Xavier |
| 10.Santa Clara | 10.Florida State |
| South Region (San Antonio) | East Region (Philadelphia) |
| 1.Duke (Greenville) | 1.Purdue (Indianapolis) |
| 16.Southern/ Nicholls State | 16.Campbell |
| 8.St. Mary’s | 8.Virginia Tech |
| 9.Drake | 9.Marquette |
| 4.Seton Hall (Buffalo) | 4.BYU (Portland) |
| 13.UAB | 13.New Mexico State |
| 5.Wisconsin | 5.Arkansas |
| 12.Iowa State/ UCF | 12.UC Riverside |
| 3.Memphis (Greenville) | 3.Arizona (San Diego) |
| 14.Colgate | 14.Georgia State |
| 6.Indiana | 6.Colorado State |
| 11.West Virginia | 11.San Francisco/ Cincinnati |
| 2.Baylor (Fort Worth) | 2.Alabama (Fort Worth) |
| 15.Hofstra | 15.Liberty |
| 7.Auburn | 7.Texas Tech |
| 10.USC | 10.St. John’s |
NIT One Seeds: Utah State, Wichita State, LSU, Providence
The Next Five: Virginia, Richmond, Mississippi State, Oklahoma, Louisville