Bracketology by Jonathon Warriner
Updated February 24th, 2021
| West Region | South Region |
| 1.Gonzaga | 1.Baylor |
| 16.Prairie View A&M/ Texas State | 16.South Dakota/ North Carolina A&T |
| 8.UCLA | 8.LSU |
| 9.Maryland | 9.Oregon |
| 4.Tennessee | 4.Creighton |
| 13.Toledo | 13.UC Santa Barbara |
| 5.Texas Tech | 5.Wisconsin |
| 12.Belmont | 12.Western Kentucky |
| 3.Iowa | 3.Houston |
| 14.Vermont | 14.Liberty |
| 6.Clemson | 6.Arkansas |
| 11.VCU | 11.San Diego State |
| 2.West Virginia | 2.Illinois |
| 15.UNC Greensboro | 15.Grand Canyon |
| 7.Florida | 7.BYU |
| 10.Drake | 10.Saint Bonaventure |
| East Region | Midwest Region |
| 1.Ohio State | 1.Michigan |
| 16.Bryant | 16.James Madison |
| 8.North Carolina | 8.Colorado |
| 9.Loyola-Chicago | 9.Boise State |
| 4.Texas | 4.Virginia |
| 13.Wright State | 13.Winthrop |
| 5.USC | 5.Kansas |
| 12.Louisville/ Minnesota | 12.Uconn/ Stanford |
| 3.Oklahoma | 3.Florida State |
| 14.Abilene Christian | 14.Navy |
| 6.Missouri | 6.Oklahoma State |
| 11.Xavier | 11.Wichita State |
| 2.Alabama | 2.Villanova |
| 15.Siena | 15.Eastern Washington |
| 7.Purdue | 7.Virginia Tech |
| 10.Colorado State | 10.Rutgers |
NIT One Seeds: Seton Hall, Indiana, Ole Miss, Utah State
The Next Five: Duke, Georgia Tech, Richmond, Saint John’s, Michigan State