Bracketology by Jonathon Warriner
Updated January 6th, 2022
| South Region (San Antonio) | East Region (Philadelphia) |
| 1.Baylor (Fort Worth) | 1.Duke (Greenville) |
| 16.Nicholls State/ Texas Southern | 16.Norfolk State/ St. Francis (PA) |
| 8.Loyola-Chicago | 8.Minnesota |
| 9.Wake Forest | 9.Oklahoma |
| 4.Alabama (Portland) | 4.Villanova (Buffalo) |
| 13.South Dakota State | 13.Iona |
| 5.UCLA | 5.Tennessee |
| 12.Creighton/ Memphis | 12.Murray State |
| 3.LSU (Greenville) | 3.Providence (Buffalo) |
| 14.Hofstra | 14.Vermont |
| 6.Seton Hall | 6.Colorado State |
| 11.San Diego State | 11.Louisville |
| 2.Wisconsin (Milwaukee) | 2.Purdue (Indianapolis) |
| 15.Liberty | 15.Princeton |
| 7.Kentucky | 7.Texas |
| 10.TCU | 10.Davidson |
| Midwest Region (Chicago) | West Region (San Francisco) |
| 1.Auburn (Fort Worth) | 1.Arizona (San Diego) |
| 16.Campbell | 16.Southern Utah |
| 8.Texas Tech | 8.Iowa |
| 9.Belmont | 9.BYU |
| 4.USC (San Diego) | 4.Xavier (Pittsburgh) |
| 13.New Mexico State | 13.Oakland |
| 5.Houston | 5.Ohio State |
| 12.UAB | 12.Chattanooga |
| 3.Michigan State (Pittsburgh) | 3.Iowa State (Indianapolis) |
| 14.Navy | 14.Ohio |
| 6.UConn | 6.Illinois |
| 11.Florida/ SMU | 11.Marquette |
| 2.Kansas (Milwaukee) | 2.Gonzaga (Portland) |
| 15.South Alabama | 15.UC Irvine |
| 7.San Francisco | 7.West Virginia |
| 10.Saint Mary’s | 10.North Carolina |
NIT One Seeds: Saint Louis, Utah State, Virginia Tech, Miami
The Next Five: Texas A&M, Mississippi State, Vanderbilt, Indiana, Michigan