Bracketology by Jonathon Warriner
Updated February 15th, 2022
| South Region (San Antonio) | West Region (San Francisco) |
| 1.Auburn (Greenville) | 1.Gonzaga (Portland) |
| 16.Appalachain State/ Colgate | 16.Long Beach State |
| 8.Iowa State | 8.Colorado State |
| 9.San Francisco | 9.TCU |
| 4.Illinois (Pittsburgh) | 4.UCLA (San Diego) |
| 13.South Dakota State | 13.North Texas |
| 5.Marquette | 5.Houston |
| 12.Chattanooga | 12.Michigan/ Creighton |
| 3.Villanova (Pittsburgh) | 3.Texas Tech (Milwaukee) |
| 14.Cleveland State | 14.Wagner |
| 6.Alabama | 6.Xavier |
| 11.Indiana | 11.Oklahoma |
| 2.Baylor (Fort Worth) | 2.Duke (Greenville) |
| 15.Montana State | 15.Norfolk State |
| 7.Wyoming | 7.Arkansas |
| 10.Wake Forest | 10.Davidson |
| East Region (Philadelphia) | Midwest Region (Chicago) |
| 1.Kansas (Fort Worth) | 1.Arizona (San Diego) |
| 16.UNC Wilmington | 16.Southern/ New Orleans |
| 8.Seton Hall | 8.St. Mary’s |
| 9.Iowa | 9.Boise State |
| 4.Tennessee (Buffalo) | 4.Michigan State (Portland) |
| 13.Ohio | 13.New Mexico State |
| 5.Ohio State | 5.LSU |
| 12.Iona | 12.North Carolina/ Kansas State |
| 3.Providence (Buffalo) | 3.Wisconsin (Milwaukee) |
| 14.Vermont | 14.Liberty |
| 6.USC | 6.Texas |
| 11.Notre Dame | 11.Memphis |
| 2.Purdue (Indianapolis) | 2.Kentucky (Indianapolis) |
| 15.Yale | 15.Longwood |
| 7.Murray State | 7.UConn |
| 10.Loyola-Chicago | 10.Miami |
NIT One Seeds: SMU, Oregon, BYU, Rutgers
The Next Five: San Diego State, Belmont, Florida, Dayton, Mississippi State