Bracketology by Jonathon Warriner
Updated January 19th, 2022
| South Region (San Antonio) | West Region (San Francisco) |
| 1.Auburn (Greenville) | 1.Gonzaga (Portland) |
| 16.Gardner-Webb/ Norfolk State | 16.Weber State |
| 8.West Virginia | 8.Miami |
| 9.Davidson | 9.Oklahoma |
| 4.Xavier (Buffalo) | 4.Iowa State (Portland) |
| 13.Louisiana Tech | 13.South Dakota State |
| 5.Ohio State | 5.UConn |
| 12.Chattanooga | 12.Wyoming/ St. Mary’s |
| 3.Texas Tech (Indianapolis) | 3.Michigan State (Pittsburgh) |
| 14.Oakland | 14.Towson |
| 6.Alabama | 6.Seton Hall |
| 11.Indiana | 11.Wake Forest |
| 2.Wisconsin (Milwaukee) | 2.Arizona (San Diego) |
| 15.Princeton | 15.UC Riverside |
| 7.BYU | 7.Colorado State |
| 10.Oregon | 10.San Francisco |
| East Region (Philadelphia) | Midwest Region (Chicago) |
| 1.Kansas (Milwaukee) | 1.Baylor (Fort Worth) |
| 16.Wagner | 16.Southern/ Southeast Louisiana |
| 8.Murray State | 8.Iowa |
| 9.Creighton | 9.Marquette |
| 4.Kentucky (Buffalo) | 4.Houston (San Diego) |
| 13.Ohio | 13.Grand Canyon |
| 5.Providence | 5.UCLA |
| 12.Iona | 12.Belmont/ Minnesota |
| 3.Duke (Greenville) | 3.Villanova (Pittsburgh) |
| 14.Liberty | 14.Vermont |
| 6.Tennessee | 6.Illinois |
| 11.TCU | 11.North Carolina |
| 2.Purdue (Indianapolis) | 2.LSU (Fort Worth) |
| 15.Navy | 15.Louisiana-Lafayette |
| 7.Loyola-Chicago | 7.USC |
| 10.San Diego State | 10.Texas |
NIT One Seeds: Texas A&M, Boise State, Florida, Florida State
The Next Five: Mississippi State, Stanford, Virginia Tech, Arkansas, Cincinnati