Bracketology by Jonathon Warriner
Updated January 17th, 2022
| South Region (San Antonio) | West Region (San Francisco) |
| 1.Auburn (Greenville) | 1.Gonzaga (Portland) |
| 16.Gardner-Webb/ Norfolk State | 16.Weber State |
| 8.Texas | 8.West Virginia |
| 9.Davidson | 9.Marquette |
| 4.Texas Tech (San Diego) | 4.Providence (Buffalo) |
| 13.Grand Canyon | 13.Louisiana Tech |
| 5.UCLA | 5.Alabama |
| 12.Wyoming/ St. Mary’s | 12.Chattanooga |
| 3.Iowa State (Indianapolis) | 3.LSU (Fort Worth) |
| 14.Liberty | 14.Towson |
| 6.UConn | 6.Illinois |
| 11.Oregon | 11.Wake Forest |
| 2.Wisconsin (Milwaukee) | 2.Arizona (San Diego) |
| 15.Lousiana-Lafayette | 15.UC Riverside |
| 7.BYU | 7.Colorado State |
| 10.San Diego State | 10.San Francisco |
| East Region (Philadelphia) | Midwest Region (Chicago) |
| 1.Kansas (Milwaukee) | 1.Baylor (Fort Worth) |
| 16.Wagner | 16.Southern/ Southeast Louisiana |
| 8.Murray State | 8.Iowa |
| 9.North Carolina | 9.Miami |
| 4.Xavier (Portland) | 4.Kentucky (Buffalo) |
| 13.South Dakota State | 13.Ohio |
| 5.Houston | 5.Ohio State |
| 12.Belmont/ Minnesota | 12.Iona |
| 3.Michigan State (Pittsburgh) | 3.Villanova (Pittsburgh) |
| 14.Oakland | 14.Vermont |
| 6.Seton Hall | 6.USC |
| 11.TCU | 11.Indiana |
| 2.Duke (Greenville) | 2.Purdue (Indianapolis) |
| 15.Navy | 15.Princeton |
| 7.Tennessee | 7.Loyola-Chicago |
| 10.Creighton | 10.Oklahoma |
NIT One Seeds: Texas A&M, Boise State, Florida, Mississippi State
The Next Five: Stanford, St. Bonaventure, Virginia Tech, Arkansas, Cincinnati