Bracketology by Jonathon Warriner
Updated February 18th, 2021
| West Region | South Region |
| 1.Gonzaga | 1.Baylor |
| 16.Prairie View A&M/ Texas State | 16.South Dakota/ North Carolina A&T |
| 8.Louisville | 8.Purdue |
| 9.Boise State | 9.North Carolina |
| 4.Virginia | 4.Creighton |
| 13.Wright State | 13.UC Santa Barbara |
| 5.Kansas | 5.Wisconsin |
| 12.Western Kentucky | 12.Toledo |
| 3.Villanova | 3.Iowa |
| 14.Vermont | 14.Liberty |
| 6.Missouri | 6.Clemson |
| 11.Indiana | 11.Drake |
| 2.Oklahoma | 2.Illinois |
| 15.Colgate | 15.Grand Canyon |
| 7.Colorado | 7.Oklahoma State |
| 10.San Diego State | 10.Oregon |
| East Region | Midwest Region |
| 1.Ohio State | 1.Michigan |
| 16.Bryant | 16.Eastern Washington |
| 8.VCU | 8.LSU |
| 9.Florida | 9.UCLA |
| 4.Florida State | 4.Texas |
| 13.Belmont | 13.Winthrop |
| 5.USC | 5.Tennessee |
| 12.Loyola-Chicago | 12.Uconn/ Stanford |
| 3.West Virginia | 3.Texas Tech |
| 14.Abilene Christian | 14.UNC Greensboro |
| 6.Rutgers | 6.Virginia Tech |
| 11.Colorado State | 11.Minnesota/ St. Bonaventure |
| 2.Alabama | 2.Houston |
| 15.Siena | 15.Northeastern |
| 7.BYU | 7.Arkansas |
| 10.Xavier | 10.Seton Hall |
NIT One Seeds: Saint John’s, Ole Miss, Maryland, Utah State
The Next Five: Richmond, Saint Louis, Syracuse, Wichita State, SMU