Bracketology by Jonathon Warriner
Updated February 19th, 2021
| West Region | South Region |
| 1.Gonzaga | 1.Baylor |
| 16.Prairie View A&M/ Texas State | 16.South Dakota/ North Carolina A&T |
| 8.Purdue | 8.LSU |
| 9.UCLA | 9.Boise State |
| 4.Florida State | 4.Creighton |
| 13.Belmont | 13.UC Santa Barbara |
| 5.Kansas | 5.Virginia Tech |
| 12.Toledo | 12.Western Kentucky |
| 3.Iowa | 3.Houston |
| 14.Vermont | 14.Liberty |
| 6.Clemson | 6.Arkansas |
| 11.Loyola-Chicago | 11.Indiana |
| 2.Oklahoma | 2.Illinois |
| 15.Colgate | 15.Grand Canyon |
| 7.Colorado | 7.Oklahoma State |
| 10.Xavier | 10.Seton Hall |
| East Region | Midwest Region |
| 1.Ohio State | 1.Michigan |
| 16.Bryant | 16.Eastern Washington |
| 8.Louisville | 8.VCU |
| 9.Florida | 9.North Carolina |
| 4.Texas | 4.Virginia |
| 13.Wright State | 13.Winthrop |
| 5.USC | 5.Tennessee |
| 12.Colorado State | 12.Uconn/ Saint Bonaventure |
| 3.Texas Tech | 3.West Virginia |
| 14.Abilene Christian | 14.UNC Greensboro |
| 6.Missouri | 6.Wisconsin |
| 11.Wichita State/ Minnesota | 11.Drake |
| 2.Alabama | 2.Villanova |
| 15.Siena | 15.Northeastern |
| 7.Rutgers | 7.BYU |
| 10.Oregon | 10.San Diego State |
NIT One Seeds: Stanford, Saint John’s, Ole Miss, Maryland
The Next Five: Utah State, Saint Louis, SMU, Richmond, Syracuse