Bracketology by Jonathon Warriner
Updated February 10th, 2022
| South Region (San Antonio) | Midwest Region (Chicago) |
| 1.Auburn (Greenville) | 1.Purdue (Indianapolis) |
| 16.Appalachain State/ Longwood | 16.Navy |
| 8.Seton Hall | 8.Murray State |
| 9.Davidson | 9.TCU |
| 4.Marquette (Buffalo) | 4.UCLA (San Diego) |
| 13.Toledo | 13.New Mexico State |
| 5.Michigan State | 5.Texas |
| 12.Iona | 12.SMU/ Creighton |
| 3.Wisconsin (Milwaukee) | 3.Villanova (Pittsburgh) |
| 14.Oakland | 14.Princeton |
| 6.LSU | 6.Ohio State |
| 11.Oklahoma | 11.Notre Dame |
| 2.Baylor (Fort Worth) | 2.Kentucky (Indianapolis) |
| 15.Norfolk State | 15.Jacksonville State |
| 7.Xavier | 7.USC |
| 10.Oregon | 10.Indiana |
| East Region (Philadelphia) | West Region (San Francisco) |
| 1.Kansas (Fort Worth) | 1.Gonzaga (Portland) |
| 16.Southern/ New Orleans | 16.Hawaii |
| 8.St. Mary’s | 8.Colorado State |
| 9.Iowa | 9.Iowa State |
| 4.Illinois (Pittsburgh) | 4.Tennessee (Portland) |
| 13.Chattanooga | 13.South Dakota State |
| 5.UConn | 5.Houston |
| 12.UAB | 12.Saint Louis/ San Diego State |
| 3.Providence (Buffalo) | 3.Texas Tech (Milwaukee) |
| 14.Vermont | 14.Wagner |
| 6.Arkansas | 6.Wyoming |
| 11.Miami | 11.Loyola-Chicago |
| 2.Duke (Greenville) | 2.Arizona (San Diego) |
| 15.UNC Greensboro | 15.Weber State |
| 7.Alabama | 7.Boise State |
| 10.Wake Forest | 10.BYU |
NIT One Seeds: Belmont, San Francisco, West Virginia, Florida
The Next Five: North Carolina, Mississippi State, Stanford, Rutgers, Washington State